Centre of Tropical Medicine: Department of Clinical Research of the BNITM and Section of Clinical Tropical Medicine of the UKE under the direction of Prof. Michael Ramharter
Our work focuses on clinically relevant aspects of infectious diseases in the tropics and their significance for travel medicine. Together with our African partners, we are involved in clinical research projects to improve treatment and prevention options in the long term.
The Lab Groups Groger and Mischlinger as well as the Leibniz Research Group Lassa-Pathophysiologie introduce themselves on the main page of the BNITM. Please click the links below to see the corresponding pages.
Leibniz Research Group Lassa-Pathophysiologie
LADEX – Dexamethasone for the treatment of Lassa fever
Lassa fever is a severe and often fatal haemorrhagic fever in humans. The disease affects a large number of countries in West Africa. The virus is mainly transmitted by contact with endemic rats and their remaining, but may also be transmitted from human to human. Vaccines are not available yet and treatment options are limited to supportive care and the drug ribavirin.
Dexamethasone is a corticosteroid which can suppress tissue inflammation. Therefore, dexamethasone is routinely used for a wide range of diseases. There is also indication that dexamethasone may be promising in severe Lassa fever. At the Irrua Specialist Teaching Hospital (ISTH) in Nigeria, one of the largest treatment centres for Lassa fever in West-Africa, dexamethasone has been successfully used in clinical practice to manage co-infections of Lassa virus and SARS-CoV-2. The combination of ribavirin and dexamethasone has been previously tested for treatment of severe Crimean-Congo haemorrhagic fever and the LADEX (LAssa fever adjunct treatment with DEXamethasone) clinical study shall explore for the first time a combination of the standard of care (ribavirin) and dexamethasone in patients with moderate to severe Lassa fever.
LADEX is a prospective open label randomized controlled phase II clinical trial with two arms:
a. Standard of care antiviral ribavirin therapy
b. Standard of care antiviral ribavirin therapy + dexamethasone
42 patients with moderate to severe Lassa fever shall be included until 2026. Study start will be at the end of 2023. BNITM is the study sponsor, recruitment of study participants will take place at ISTH.
The aim of this trial is to improve the outcome of patients suffering from moderate to severe Lassa fever
Ongoing Projects
eWHORM – Enabling the WHO-Road Map 2030
Worm infections (helminthioses) affect about 1.5 billion people worldwide, making them one of the most common human infections. Parasitic worms (helminths) are often transmitted through insect bites or contaminated soil in areas with limited access to clean water, sanitation and healthcare. These infections can cause chronic and debilitating health problems, such as lymphatic filariasis, onchocerciasis (river blindness), loiasis (African eye worm), mansonellosis and trichuriasis (whipworm infection).
To combat various soil-transmitted helminths (STH) and filarial worms, a new multidisciplinary consortium of research institutes, universities and non-profit organisations in sub-Saharan Africa (SSA) and Europe will work together to establish a new adaptive clinical trials platform and improve clinical research infrastructure in several SSA countries. While each partner will bring unique expertise and complementary experience to achieve the project's goals, strong representation from the Global South will drive eWHORM activities. eWHORM is coordinated by the University Hospital of Bonn and funded with €7.9 million from the European Union's EDCTP (European and Developing Countries Clinical Trials Partnership) programme and a further €3.4 million from the Swiss government over the next five years.
Despite significant progress in the prevention and control of helminthioses, many of the existing drugs have proven problematic in terms of efficacy, treatment duration and safety.
The eWHORM project aims to solve the further development and testing of more effective and safe treatment options that work on different helminth species. The project will also train health professionals to diagnose multiple diseases in four endemic countries: the Democratic Republic of Congo, Gabon, Cameroon and Tanzania.
This major step will help achieve two urgent WHO goals: (1) the elimination of filarial and STH infections and (2) capacity building in endemic countries.
The project is coordinated by Prof Marc Hübner, University Hospital Bonn, Germany, other project partners are:
The Bernhard Nocht Institute for Tropical Medicine is responsible for conducting the clinical trials on loiasis together with CERMEL, Gabon, and the eWHORM consortium.
Please find further information on this project https://ewhorm.org/.
LoloMox: A randomised clinical trial to evaluate the safety and tolerability of moxidectin in microfilarial L.loa patients
Loiasis is endemic in Central and West Africa and a neglected filarial disease that has received little scientific attention. Yet it has now been shown that the burden of disease and the associated increased mortality is comparable to other neglected tropical diseases such as schistosomiasis. Many loiasis patients remain untreated due to the lack of drugs for individual treatment or drug control programmes.
Due to its pharmacological characteristics, moxidectin is a potential candidate for the drug therapy of loiasis. It was already approved by the FDA in 2018 for the therapy of onchocerciasis after positive study results. The aim of the LoloMox project is to provide initial evidence for the safety, tolerability and efficacy of moxidectin in the treatment of loiasis in endemic regions.
The DZIF-funded study is being implemented at CERMEL in Lambaréné, Gabon. The focus is on evaluating the tolerability of moxidectin in the first 28 days after drug intake. In addition, the study participants will be followed up over a period of 18 months to investigate the effectiveness of the therapy based on parasitological and clinical parameters.
The Department of Clinical Research at BNITM, under the direction of Prof. Ramharter, will assume the role of sponsor. Prof. Mombo-Ngoma at CERMEL will take the lead as Principle Investigator. Other partners for LoloMox are the Institute for Medical Microbiology, Immunology and Parasitology (IMMIP) at the University Hospital Bonn, Germany and the Institute of Research for Development (IRD) at the Université de Montpellier in France.
Clinical evaluation of AntimalarialS tri-therapy with AtovAquone Proguanil for malaria treatment in African children (ASAAP)
ASAAP is a 48-month lasting clinical trial research to evaluate the efficacy, safety, tolerability and pharmacokinetics of a new antimalarial drug combination, with particular focus on its successful application in one of the largest and most vulnerable demographics of Africa – i.e. children 0-5 years old. The overall aim is to develop new antimalarial treatments by combining existing, efficacious medicines for treatment of malaria in African children by promoting African and European research collaboration and strengthening the capacity of African institutions to conduct clinical research.
ASAAP is part of the European and Developing Countries Clinical Trials Partnership 2 (EDCTP2) program supported by the European Union (EU) and receives funding from the German Federal Ministry of Education and Research (BMBF) and the National Institut of Health and Medical Research in France (INSERM).
The project is being led and coordinated by Dr. Oumou Maiga-Ascofaré of the BNITM in Hamburg, Germany and the KCCR in Kumasi, Ghana under the authority of the Kwame Nkrumah University of Science and Technology (KNUST), in collaboration with:
Further information can be found on the EDCTP homepage (https://www.edctp.org/) and on the project homepage (https://asaap-malaria.org/).
Abgeschlossene Projekte
Establishment of clinical study sites and conduct of drug trials to improve Lassa fever treatment in endemic regions
Most African countries are unable to reliably diagnose pathogens with epidemic potential and respond adequately to outbreaks. The widespread lack of these capacities has contributed to the delayed response to the Ebola virus outbreak in West Africa. In addition, there is the lack of medical countermeasures for diseases with epidemic potential that have their origin in Africa. These diseases also include Lassa fever which is, similar to the Ebola virus disease, a so-called viral hemorrhagic fever. It is endemic in much of western Africa. Hundreds of thousands of infections are estimated every year and the mortality rate in the hospital is around 30%. There is no vaccine or evidence based treatment available. For these reasons, the WHO put Lassa fever on the list of diseases with urgent R&D needs.
This project will build capacity in Nigeria to rapidly contain Lassa fever outbreaks and develop medical countermeasures for Lassa fever disease. To do so, it is necessary to review existing therapeutic options (ribavirin) because of doubts about the drug’s efficacy and, at the same time, to investigate new drug candidates (e.g. favipiravir) in humans. Therefore, appropriate capacity for on-site clinical studies must be built and initial studies need to be conducted collaboratively.
Together with the Irrua Specialist Teaching Hospital (ISTH) in Edo State, capacities are built up in Nigeria and medication studies are initiated to build up local expertise:
The SAFARI project is carried out in collaboration with the FMCO in Ondo State, Nigeria, the Institute National de la Santé et de la Recherche Médicale (Inserm), the Université Bordeaux and the Alliance for International Medical Action (ALIMA).
Further information on this project can be found on the GHPP (Global Health Protection Program) homepage under https://ghpp.de/de/projekte/lassa-nigeria/.
TROPICSAFE - Medizinischer Transport von Patienten mit tropischen Erkrankungen unter sicheren Umständen
Der Patiententransport ist eine gefährliche Aufgabe, wenn Fachkräfte mit ansteckenden Krankheiten zu kämpfen haben. Heutzutage gibt es mehrere Protokolle zur Behandlung von Tropenkrankheiten, die Angehörigen der Gesundheitsberufe fordern jedoch spezifische Richtlinien und praktischeres Schulungsmaterial mit standardisierten Kriterien. Darüber hinaus macht der Schengen-Raum mit der Aufhebung der Binnengrenzen in der EU gemeinsame Strategien und Verfahren erforderlich, um einem möglichen Ausbruch von Viren durch transnationale Maßnahmen entgegenzuwirken.
Das TROPICSAFE-Projekt zielt darauf ab, ein standardisiertes Trainingsprotokoll auf europäischer Ebene zu entwickeln, das sich auf die Beförderung von Patienten mit Tropenkrankheiten konzentriert.
Diese Schulung wird auf einer Open Online Learning Platform veröffentlicht. Die Schulung umfasst audiovisuelle Unterstützung, z. B. Videos, Bilder und Grafiken, um die Sicherheitsverfahren, die vom Fachpersonal befolgt werden sollten, besser zu veranschaulichen. Sie wird mit Fragen- und Antworttests zur Bewertung des Schulungsprozesses abgeschlossen und in die Sprachen der Arbeitsgemeinschaft übersetzt.
Die Arbeitsgemeinschaft setzt sich aus fünf Institutionen zusammen, die den Sektor in ihrem Land genau kennen und die Interessen von Arbeitnehmern, Angehörigen der Gesundheitsberufe und Ausbildern vertreten. Unter der Leitung des BNITM sind folgende weitere Einrichtungen an diesem Projekt beteiligt:
Das Projekt wird vom ERASMUS+ Programm der EU über 24 Monate mitfinanziert.
FAIR - Fighting Antibiotic Resistances
DVT-Study - Deep Vein Thrombosis Study
HHECO - The impact of Helicobacter pylori co-infection on immune regulation and clinical course in HIV patients in Ghana
Recently, the interplay between Human immunodeficiency virus (HIV) and Helicobacter pylori infection has attracted attention. A number of studies reported more favorable immune and clinical parameters in HIV-infected individuals with H. pylori. The inverse relationship between H. pylori infection and immunocompetence of the host is unexpected, since most chronic infections are more common in patients with progressed HIV disease.
We aim to investigate the impact of H. pylori and other relevant co-infections on immune activation and clinical outcomes in a cohort of 1000 HIV-positive patients at the Komfo Anokye Teaching Hospital in Kumasi, Ghana.
KCS - Kumasi Cohort Study on the efficacy of first and second line ART in HIV patients in Ghana
As of 2011, 56 000 adult people living with HIV (PLHIV) were treated with antiretroviral drugs in Ghana. This represents a fourth of all adult PLHIV in Ghana and a 47% coverage among people with advanced HIV infection.
In a cohort of 1500 HIV-infected patients on first-line ART at the Komfo Anokye Teaching Hospital in Kumasi, the proportion of treatment failures and its determinates should be investigated. During this study, we established a cohort of PLHIV switched to second-line ART after virological or immunological treatment failure. Here as well, we aim to investigate the efficacy of this second-line ART, which is of high interest due to the fact that there is no third-line option available in Ghana.
Awards
DTG Prize for Tropical Medicine 2023, Johannes Mischlinger (June 2023)
DTG Poster Award, Charlotte Kriebel (June 2023)
Wolfgang Stille Science Prize 2022 (PEG), Mirjam Groger (February 2023)
BNITM Research Highlight, Q2 2022, Mirjam Groger (July 2022)
VdF PhD Award for Medicine 2022, Luzia Veletzky (June 2022)
DTG Poster Award, Hannah Müller (June 2022)
DTG Prize for Tropical Medicine 2021, Dr. Benno Kreuels (June 2021)
Dr. Martini Prize 2021, Luzia Veletzky (February 2021)
BNITM Research Highlight, Q2 2020, Luzia Veletzky (June 2020)
VdF PhD Award for Medicine 2020, Johannes Mischlinger (September 2020)
DZIF-DGI PhD Prize 2019, Till Omansen (November 2019)
Stephan Weiland Prize 2019, Johannes Mischlinger (September 2019)
VdF PhD Award for Medicine 2019, Mirjam Groger (June 2019)
ISTM Research Award 2019, Silja Bühler (April 2019)
DTG Poster Award, Mirjam Groger (April 2019)
ÖGTPM Travel Grant, Mirjam Groger (March 2019)
Dr. Martini Prize 2019, Johannes Mischlinger (February 2019)
ASTMH Young Investigator Award “Honorable mentionee”, Johannes Mischlinger (Oktober 2018)
ASTMH Young Investigator Award “Honorable mentionee”, Luzia Veletzky (October 2018)
BNITM Research Highlight, Q4 2018, Johannes Mischlinger (October 2018)
CERMEL Research Award 2018, Prof. Michael Ramharter (2018)
Poster Award at the Congress on Infectious Diseases and Tropical Medicine, Christof Vinnemeier (June 2018)
Graduations
Dr. med. univ. Luzia Veletzky, PhD (2021)
Till Omansen, PhD (2020)
Dr. med. univ. Johannes Mischlinger, PhD (2019)
Dr. med. univ, Mirjam Groger, PhD (2018)
The Bernhard Nocht Centre for Clinical Trials (BNCCT) is part of the 1st Department of Tropical Medicine of the University Medical Center Hamburg-Eppendorf (UKE). It is located in the historic building of the Bernhard Nocht Institute for Tropical Medicine (BNITM).
Since 2008 the BNCCT performs vaccine trials and offers comprehensive services relating to the conduct of clinical trials in the areas of travel medicine and tropical medicine .
Our services include the management of multicenter clinical trials (e.g. RCTs, IITs), development of regulatory documents, consulting services related to study and protocol design as well as data and safety monitoring.
Further information on the Bernhard Nocht Centre for Clinical Trials (BNCCT) can be found here:
A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria
Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group.
BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study
Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, Kakolwa MA, Vala A, Accrombessi M, Briand V, Aponte JJ, Manego Zoleko R, Adegnika AA, Cot M, Kremsner PG, Massougbodji A, Abdulla S, Ramharter M, Macete E, Menéndez C.
PLoS Med. 2016 Feb 23;13(2):e1001964. doi: 10.1371/journal.pmed.1001964. eCollection 2016 Feb.
Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA.
N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924. Epub 2015 Apr 1
Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial
Basra A, Mombo-Ngoma G, Melser MC, Diop DA, Würbel H, Mackanga JR, Fürstenau M, Zoleko RM, Adegnika AA, Gonzalez R, Menendez C, Kremsner PG, Ramharter M.
Clin Infect Dis. 2013 Mar;56(6):e68-75. doi: 10.1093/cid/cis976. Epub 2012 Nov 21.
Do paediatric drug formulations of artemisinin combination therapies improve the treatment of children with malaria? A systematic review and meta-analysis
Kurth F, Bélard S, Adegnika AA, Gaye O, Kremsner PG, Ramharter M.
Lancet Infect Dis. 2010 Feb;10(2):125-32. doi: 10.1016/S1473-3099(09)70327-5.
Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon
Ramharter M, Kurth F, Schreier AC, Nemeth J, Glasenapp Iv, Bélard S, Schlie M, Kammer J, Koumba PK, Cisse B, Mordmüller B, Lell B, Issifou S, Oeuvray C, Fleckenstein L, Kremsner PG.
J Infect Dis. 2008 Sep 15;198(6):911-9. doi: 10.1086/591096.
Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial
Ramharter M, Oyakhirome S, Klein Klouwenberg P, Adégnika AA, Agnandji ST, Missinou MA, Matsiégui PB, Mordmüller B, Borrmann S, Kun JF, Lell B, Krishna S, Graninger W, Issifou S, Kremsner PG.
Clin Infect Dis. 2005 Jun 15;40(12):1777-84. Epub 2005 May 3.
Clinical and parasitological characteristics of puerperal malaria
Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG.
J Infect Dis. 2005 Mar 15;191(6):1005-9. Epub 2005 Feb 4.
Shared breastfeeding in central Africa
Ramharter M, Chai SK, Adegnika AA, Klöpfer A, Längin M, Agnandji ST, Oyakhirome S, Schwarz NG, Grobusch MP, Issifou S, Kremsner PG.
AIDS. 2004 Sep 3;18(13):1847-9.
Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria
Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C.
Clinical Infectious Diseases, Volume 76, Issue 3, 1 February 2023, Pages e841–e848, https://doi.org/10.1093/cid/ciac578
Impact of antibiotic intake on the incidence of extended-spectrum β-lactamase-producing Enterobacterales in sub-Saharan Africa: results from a community-based longitudinal study.
Heinemann M, Kleinjohann L, Rolling T, Winter D, Hackbarth N, Ramharter M, Addo M, Eibach D, Phillips RO, Owusu-Ofori A, Vinnemeier CD.
Clin Microbiol Infect. 2023 Mar;29(3):340-345. doi: 10.1016/j.cmi.2022.09.008. Epub 2022 Sep 20. PMID: 36150674
Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial
Mirjam Groger, Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Nsengi Y Ntamabyaliro, Gauthier Kahunu Mesia, Trésor Bodjick Muena Mujobu, Lia Betty Dimessa Mbadinga, Rella Zoleko Manego, Diane Egger-Adam, Isabelle Borghini-Fuhrer, Jangsik Shin, Robert Miller, Sarah Arbe-Barnes, Stephan Duparc, Michael Ramharter
Lancet Microbe . 2022 May 30;S2666-5247(22)00092-1. doi: 10.1016/S2666-5247(22)00092-1. Online ahead of print.
Challenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria
Bassat Q, Maïga-Ascofaré O, May J, Clain J, Mombo-Ngoma G, Groger M, Adegnika AA, Agobé JD, Djimde A, Mischlinger J, Ramharter M; ASAAP and Multimal Consortia.
Malar J. 2022 Feb 22;21(1):61. doi: 10.1186/s12936-022-04079-9. PMID: 35193586; PMCID: PMC8864855.
Drug-induced hypersensitivity to artemisinin-based therapies for malaria
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol . 2022 Feb;38(2):136-146. doi: 10.1016/j.pt.2021.08.011. Epub 2021 Sep 21.
Pharmacokinetics of ribavirin in the treatment of Lassa fever: An observational clinical study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria.
Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C.
Clin Infect Dis. 2022 Jul 26:ciac578. doi: 10.1093/cid/ciac578. Epub ahead of print. PMID: 35881530. (open access)
Multicentric Evaluation of SeeGene Allplex Real-Time PCR Assays Targeting 28 Bacterial, Microsporidal and Parasitic Nucleic Acid Sequences in Human Stool Samples.
Weinreich F, Hahn A, Eberhardt KA, Kann S, Köller T, Warnke P, Dupke S, Dekker D, May J, Frickmann H, Loderstädt U.
Diagnostics (Basel). 2022 Apr 16;12(4):1007. doi: 10.3390/diagnostics12041007.
Psychomotor development in two-year-old Ivorian and Ghanaian children - Psychometric properties of the Kilifi Developmental Inventory.
Barthel D, Kriston L, Yao ED, Fordjour D, Armel KEJ, Eberhardt KA, Hinz R, Ehrhardt S, Bindt C; International CDS Study Group.
Br J Dev Psychol. 2022 Jul 15. doi: 10.1111/bjdp.12428.
Treatment Failure in Vertebral Osteomyelitis - Is it all about Staphylococcus aureus?
Yagdiran A, Jochimsen D, Kernich N, Herden J, Eysel P, Eberhardt KA, Jung N.
Spine (Phila Pa 1976). 2022 Jul 15. doi: 10.1097/BRS.0000000000004420.
Comparative Evaluation of Real-Time Screening PCR Assays for Giardia duodenalis and of Assays Discriminating the Assemblages A and B.
Weinreich F, Hahn A, Eberhardt KA, Kann S, Feldt T, Sarfo FS, Di Cristanziano V, Frickmann H, Loderstädt U.
Microorganisms. 2022 Jun 28;10(7):1310. doi: 10.3390/microorganisms10071310.
The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana.
Sarfo FS, Dompreh A, Asibey SO, Boateng R, Weinreich F, Kuffour EO, Norman B, Di Cristanziano V, Frickmann H, Feldt T, Eberhardt KA.
Microorganisms. 2022 Jul 13;10(7):1407. doi: 10.3390/microorganisms10071407.
Screening for Schistosoma spp. and Leishmania spp. DNA in Serum of Ghanaian Patients with Acquired Immunodeficiency.
Weinreich F, Hahn A, Hagen RM, Rohde H, Sarfo FS, Feldt T, Dompreh A, Asibey SO, Boateng R, Frickmann H, Eberhardt KA.
Pathogens. 2022 Jul 2;11(7):760. doi: 10.3390/pathogens11070760.
Performance of Field's Stain Compared with Conventional Giemsa Stain for the Rapid Detection of Blood Microfilariae in Gabon.
Mbassi FE, Mombo-Ngoma G, Ndoumba WN, Yovo EK, Eberhardt KA, Mbassi DE, Adegnika AA, Agnandji ST, Bouyou-Akotet MK, Ramharter M, Zoleko-Manego R.
Am J Trop Med Hyg. 2022 Jul 5:tpmd220061. doi: 10.4269/ajtmh.22-0061.
Malaria and its importance in travel medicine
Mischlinger J, Jochum J, Ramharter M, Kurth F.
Dtsch Med Wochenschr. 2022 Jun;147(12):745-755. doi: 10.1055/a-1661-3783. Epub 2022 Jun 7. PMID: 35672022
Leishmania infantum reactivation with secondary IgA nephropathy.
Grewe I, Brehm TT, Kreuels B, Steinmetz OM, Dumoulin B, Asemissen AM, Tappe D, Ramharter M, Schmiedel S.
J Travel Med. 2022 Mar 14:taac038. doi: 10.1093/jtm/taac038. Online ahead of print. PMID: 35285886
Corrigendum to: Molecular Epidemiology of Mansonella Species in Gabon.
Sandri TL, Kreidenweiss A, Cavallo S, Weber D, Juhas S, Rodi M, Woldearegai TG, Gmeiner M, Veletzky L, Ramharter M, Tazemda-Kuitsouc GB, Matsiegui PB, Mordmüller B, Held J.
J Infect Dis. 2022 Mar 2;225(5):929. doi: 10.1093/infdis/jiab439. PMID: 35106595
Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis.
Hotz JF, Kaczirek K, Stremitzer S, Waneck F, Auer H, Perkmann T, Kussmann M, Bauer PK, Chen RY, Kriz R, Burgmann H, Ramharter M, Lagler H.
Pathogens. 2022 Feb 18;11(2):261. doi: 10.3390/pathogens11020261. PMID: 35215203
Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project).
González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C.
BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197. PMID: 34815285
Correction: Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma.
Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A.
2022 Jun 2;16(6):e0010512. doi: 10.1371/journal.pntd.0010512. eCollection 2022 Jun. PMID: 35653329
A standardised Phase III clinical trial framework to assess therapeutic interventions for Lassa fever.
Olayinka AT, Bourner J, Akpede GO, Okoeguale J, Abejegah C, Ajayi NA, Akude C, Ayodeji O, Bausch DG, de Clerck H, Dan-Nwafor C, Dunning J, Erameh C, Eze JN, Formenty P, Gillesen A, Jalloh S, Jaspard M, Jegede T, Maikere J, Malvy D, Ogbaini-Emovon E, Ojo OE, Okogbenin S, O'Neill K, Orji ML, Owhin SO, Ramharter M, Samuels RJ, Shehu N, Merson L, Salam AP, Kayem ND, Horby P, Ihekweazu C, Olliaro P.
PLoS Negl Trop Dis. 2022 Jan 6;16(1):e0010089. doi: 10.1371/journal.pntd.0010089. eCollection 2022 Jan. PMID: 34990453
Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambaréné, Gabon.
Essone PN, Adegbite BR, Mbadinga MJM, Mbouna AV, Lotola-Mougeni F, Alabi A, Edoa JR, Lell B, Alabi AS, Adegnika AA, Ramharter M, Siawaya JFD, Grobusch MP, Kremsner PG, Agnandji ST.
Infection. 2022 Aug;50(4):897-905. doi: 10.1007/s15010-022-01760-8. Epub 2022 Feb 8. PMID: 35133607
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M.
Eur J Immunol. 2022 Feb;52(2):312-327. doi: 10.1002/eji.202149424. Epub 2021 Nov 25. PMID: 34752634
Attitudes, practices, and obstacles towards influenza vaccination for international travelers among travel health advisors in Germany: A questionnaire-based survey.
Brehm TT, Jordan S, Addo MM, Ramharter M, Kreuels B.
Travel Med Infect Dis. 2022 Jan-Feb;45:102233. doi: 10.1016/j.tmaid.2021.102233. Epub 2021 Dec 8. PMID: 34890809
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis.
(Ramharter) WorldWide Antimalarial Resistance Network Methodology Study Group.
Malar J. 2022 Mar 24;21(1):106. doi: 10.1186/s12936-021-03980-z. PMID: 35331243
Deciphering the Plasmodium falciparum malaria-specific CD4+ T-cell response: ex vivo detection of high frequencies of PD-1+TIGIT+ EXP1-specific CD4+ T cells using a novel HLA-DR11-restricted MHC class II tetramer.
Schulte S, Heide J, Ackermann C, Peine S, Ramharter M, Mackroth MS, Woost R, Jacobs T, Schulze Zur Wiesch J.
Clin Exp Immunol. 2022 Apr 4;207(2):227-236. doi: 10.1093/cei/uxab027. PMID: 35020841
Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data.
(Ramharter) WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group.
BMC Med. 2022 Mar 7;20(1):85. doi: 10.1186/s12916-022-02265-9. PMID: 35249546
Risk-adjusted active tuberculosis case finding strategy in central Ethiopia.
Fuchs A, Tufa TB, Pfäfflin F, Schönfeld A, Nordmann T, Melaku F, Sorsa A, Orth HM, Häussinger D, Luedde T, Feldt T.
IJID Reg. 2022 Mar 20;3:196-203. doi: 10.1016/j.ijregi.2022.03.012. PMID: 35755475; PMCID: PMC9216629.
Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia.
Tufa TB, Mackenzie CR, Orth HM, Wienemann T, Nordmann T, Abdissa S, Hurissa Z, Schönfeld A, Bosselmann M, Häussinger D, Pfeffer K, Luedde T, Fuchs A, Feldt T.
Antimicrob Resist Infect Control. 2022 Jan 15;11(1):8. doi: 10.1186/s13756-022-01053-7. PMID: 35033191; PMCID: PMC8761287.
Parasites - important endemic and imported pathogens.
Jordan S, Kreuels B.
Dtsch Med Wochenschr. 2022 Jun;147(11):687-696. doi: 10.1055/a-1664-7518. Epub 2022 May 30. PMID: 35636420 Review. German.
Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022.
Nörz D, Pfefferle S, Brehm TT, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp EM, Jordan S, Addo MM, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M, Knobloch JK.
Euro Surveill. 2022 Jun;27(26). doi: 10.2807/1560-7917.ES.2022.27.26.2200477. PMID: 35775427
Imitation eines Felty-Syndroms durch eine viszerale Leishmaniasis bei rheumatoider Arthritis unter Therapie mit Methotrexat und Etanercept.
Ruffer, N., Tomas, N. M., Schmiedel, S., Jordan, S. & Kötter, I.
Z Rheumatol. 2022 Apr;81(3):244. doi: 10.1007/s00393-021-01143-8. PMID: 34932148 German. No abstract available.
Inflammatory cytokine profile and T cell responses in African tick bite fever patients.
Rauch J, Jochum J, Eisermann P, Gisbrecht J, Völker K, Hunstig F, Mehlhoop U, Muntau B, Tappe D.
Med Microbiol Immunol. 2022 Jun;211(2-3):143-152. doi: 10.1007/s00430-022-00738-5. Epub 2022 May 11. PMID: 35543881
High-resolution analysis of individual spike peptide-specific CD4+ T-cell responses in vaccine recipients and COVID-19 patients.
Karsten H, Cords L, Westphal T, Knapp M, Brehm TT, Hermanussen L, Omansen TF, Schmiedel S, Woost R, Ditt V, Peine S, Lütgehetmann M, Huber S, Ackermann C, Wittner M, Addo MM, Sette A, Sidney J, Schulze Zur Wiesch J.
Clin Transl Immunology. 2022 Aug 9;11(8):e1410. doi: 10.1002/cti2.1410. eCollection 2022. PMID: 35957961
Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B
PA-COVID-19 Study Group. Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. PMID: 35032429
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.
Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Schommers P, Lehmann C, Kurth F, Sander LE, Klein F.
Nat Med. 2022 Mar;28(3):477-480. doi: 10.1038/s41591-021-01676-0. Epub 2022 Jan 19. PMID: 35046572
Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Respir Med. 2022 Jan;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub 2021 Dec 1. PMID: 34871947
Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections.
Tober-Lau P, Gruell H, Vanshylla K, Koch WM, Hillus D, Schommers P, Suárez I, Suttorp N, Sander LE, Klein F, Kurth F.
Emerg Infect Dis. 2022 May;28(5):1050-1052. doi: 10.3201/eid2805.220271. Epub 2022 Mar 8. PMID: 35259088
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns.
Gruell H, Vanshylla K, Korenkov M, Tober-Lau P, Zehner M, Münn F, Janicki H, Augustin M, Schommers P, Sander LE, Kurth F, Kreer C, Klein F.
Cell Host Microbe. 2022 Jul 7:S1931-3128(22)00318-3. doi: 10.1016/j.chom.2022.07.002. Online ahead of print. PMID: 35921836
Durability of omicron-neutralising serum activity after mRNA booster immunisation in older adults.
Vanshylla K, Tober-Lau P, Gruell H, Münn F, Eggeling R, Pfeifer N, Le NH, Landgraf I, Kurth F, Sander LE, Klein F.
Lancet Infect Dis. 2022 Apr;22(4):445-446. doi: 10.1016/S1473-3099(22)00135-9. Epub 2022 Feb 28. PMID: 35240040
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Degenhardt F, Ellinghaus D, Juzenas S, Kurth F, et al..
Hum Mol Genet. 2022 Jul 15:ddac158. doi: 10.1093/hmg/ddac158. Online ahead of print. PMID: 35848942
Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19.
Vasbinder A, Anderson E, Shadid H, Kurth F, et.al..
Diabetes Care. 2022 Mar 1;45(3):692-700. doi: 10.2337/dc21-2102. PMID: 35045184
The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics.
Schons M, Pilgram L, Reese JP, Stecher M, Kurth F, et al..
NAPKON Research Group. Eur J Epidemiol. 2022 Jul 29:1-22. doi: 10.1007/s10654-022-00896-z. Online ahead of print. PMID: 35904671
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies.
Akbil B, Meyer T, Stubbemann P, Kurth F, et al..
J Clin Immunol. 2022 May 5:1-19. doi: 10.1007/s10875-022-01252-2. Online ahead of print. PMID: 35511314
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. PMID: 34861681
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum R, Suwalski P, Kurth F, et al..
EClinicalMedicine. 2022 Jun;48:101438. doi: 10.1016/j.eclinm.2022.101438. Epub 2022 May 14. PMID: 35600330
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Lingscheid T, Lippert LJ, Hillus D, Kurth F et al..
Infection. 2022 Apr 14:1-12. doi: 10.1007/s15010-022-01796-w. Online ahead of print. PMID: 35420370
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study.
Wang Z, Cryar A, Lemke O, Kurth F, et al..
EClinicalMedicine. 2022 Jul;49:101495. doi: 10.1016/j.eclinm.2022.101495. Epub 2022 Jun 9. PMID: 35702332
A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021.
Wulf Hanson S, Abbafati C, Aerts JG, Al-Aly Z, Kurth F, et al..
medRxiv. 2022 May 27:2022.05.26.22275532. doi: 10.1101/2022.05.26.22275532. Preprint. PMID: 35664995
Attitude toward a mandatory COVID-19 vaccination policy and its determinants: Evidence from serial cross-sectional surveys conducted throughout the pandemic in Germany.
Sprengholz P, Korn L, Eitze S, Felgendreff L, Siegers R, Goldhahn L, De Bock F, Huebl L, Böhm R, Betsch C.
Vaccine. 2022 Feb 7:S0264-410X(22)00130-X. doi: 10.1016/j.vaccine.2022.01.065. Online ahead of print. PMID: 35153092
Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19.
Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, Marget M, Peine S, Johansson AM, Sette A, Lütgehetmann M, Kwok WW, Sidney J, Schulze Zur Wiesch J.
PLoS Pathog. 2022 Jan 5;18(1):e1010220. doi: 10.1371/journal.ppat.1010220. eCollection 2022 Jan. PMID: 34986197
Long-term persistence of antibodies after diphtheria/tetanus vaccination in immunosuppressed patients with inflammatory rheumatic diseases and healthy controls.
Mischlinger J, Jaeger VK, Ciurea A, Gabay C, Hasler P, Mueller RB, Siegrist CA, Villiger P, Walker UA, Hatz C, Bühler S.
Vaccine. 2022 Aug 5;40(33):4897-4904. doi: 10.1016/j.vaccine.2022.06.013. Epub 2022 Jul 7. PMID: 35810064
Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells.
Dalimot JJ, Klei TRL, Beuger BM, Dikmen Z, Bouwman SAM, Mombo-Ngoma G, Zoleko-Manego R, Ndzebe-Ndoumba WF, Egée S, Kuijpers TW, Grobusch MP, van Bruggen R.
Blood Adv. 2022 Mar 29:bloodadvances.2021006171. doi: 10.1182/bloodadvances.2021006171. Online ahead of print. PMID: 35349634
Drug-induced hypersensitivity to artemisinin-based therapies for malaria.
Nordmann T, Borrmann S, Ramharter M.
Trends Parasitol . 2022 Feb;38(2):136-146. doi: 10.1016/j.pt.2021.08.011.
Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study.
Zoleko-Manego R, Okwu DG, Handrich C, Dimessa-Mbadinga LB, Akinosho MA, Ndzebe-Ndoumba WF, Davi SD, Stelzl D, Veletzky L, Kreidenweiss A, Nordmann T, Adegnika AA, Lell B, Kremsner PG, Ramharter M, Mombo-Ngoma G.
PLoS Negl Trop Dis . 2022 Oct 31;16(10):e0010899.
Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections.
Okogbenin S, Erameh C, Okoeguale J, Edeawe O, Ekuaze E, Iraoyah K, Agho J, Groger M, Kreuels B, Oestereich L, Babatunde FO, Akhideno P, Günther S, Ramharter M, Omansen T.
Emerg Infect Dis. 2022 Oct;28(10):2060-2063. doi: 10.3201/eid2810.220625. PMID: 36148915; PMCID: PMC9514364.
Alveolar echinococcosis in immunocompromised hosts.
Autier B, Gottstein B, Millon L, Ramharter M, Gruener B, Bresson-Hadni S, Dion S, Robert-Gangneux F.
Clin Microbiol Infect. 2022 Dec 14:S1198-743X(22)00630-9. doi: 10.1016/j.cmi.2022.12.010. Online ahead of print. PMID: 36528295
Leishmania infantum reactivation with secondary IgA nephropathy
Grewe I, Brehm TT, Kreuels B, Steinmetz OM, Dumoulin B, Asemissen AM, Tappe D, Ramharter M, Schmiedel S.
J Travel Med. 2022 Nov 4;29(7):taac038. doi: 10.1093/jtm/taac038. PMID: 35285886
Impact of antibiotic intake on incidence of extended spectrum beta-lactamase producing Enterobacterales in sub-Saharan Africa - results from a community-based longitudinal study.
Heinemann M, Kleinjohann L, Rolling T, Winter D, Hackbarth N, Ramharter M, Addo M, Eibach D, Phillips RO, Owusu-Ofori A, Vinnemeier CD.
Clin Microbiol Infect. 2022 Sep 20:S1198-743X(22)00476-1. doi: 10.1016/j.cmi.2022.09.008. Online ahead of print. PMID: 36150674
Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon.
Veletzky L, Eberhardt KA, Hergeth J, Stelzl DR, Zoleko Manego R, Mombo-Ngoma G, Kreuzmair R, Burger G, Adegnika AA, Agnandji ST, Matsiegui PB, Boussinesq M, Mordmüller B, Ramharter M.
PLoS Negl Trop Dis. 2022 Sep 19;16(9):e0010793. doi: 10.1371/journal.pntd.0010793. eCollection 2022 Sep. PMID: 36121900
Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials.
Pons-Duran C, Mombo-Ngoma G, Macete E, Desai M, Kakolwa MA, Zoleko-Manego R, Ouédragou S, Briand V, Valá A, Kabanywanyi AM, Ouma P, Massougbodji A, Sevene E, Cot M, Aponte JJ, Mayor A, Slutsker L, Ramharter M, Menéndez C, González R.
PLoS Med. 2022 Sep 2;19(9):e1004084. doi: 10.1371/journal.pmed.1004084. eCollection 2022 Sep. PMID: 36054101
Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial.
Kurth F, Helbig ET, Lippert LJ, Thibeault C, Barbone G, Eckart MA, Kluge M, Puengel T, Demir M, Röhle R, Keller T, Ruwwe-Glösenkamp C, Witzenrath M, Suttorp N, von Kalle C, Sander LE, Jochum C, Tacke F.
J Glob Antimicrob Resist. 2022 Dec 23:S2213-7165(22)00363-0. doi: 10.1016/j.jgar.2022.12.004. Online ahead of print. PMID: 36572146
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.
Infection. 2022 Dec;50(6):1441-1452. doi: 10.1007/s15010-022-01796-w. Epub 2022 Apr 14. PMID: 35420370
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Kurth F,; STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Gonzalez Cejudo T, Landmesser.
Hum Mol Genet. 2022 Nov 28;31(23):3945-3966. doi: 10.1093/hmg/ddac158. PMID: 35848942
Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis.
Lingscheid T, Kinzig M, Krüger A, Müller N, Bölke G, Tober-Lau P, Münn F, Kriedemann H, Witzenrath M, Sander LE, Sörgel F, Kurth F.
Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. doi: 10.1128/aac.01229-22. Epub 2022 Oct 26. PMID: 36286542
Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021.
Global Burden of Disease Long COVID Collaborators, Wulf Hanson S, Abbafati C, Aerts JG, Al-Aly Z, Ashbaugh C, Ballouz T, Blyuss O, Bobkova P, Bonsel G, Borzakova S, Buonsenso D, Kurth F, Larsson IM, Lipcsey M, Liu C, Loflin CD, Malinovschi A, Mao W, Mazankova L, McCulloch D, Menges D, Mohammadifard N, Munblit D, Nekliudov NA, Ogbuoji O, Osmanov IM, Peñalvo JL, Petersen MS, Puhan MA, Rahman M, Rass V, Reinig N, Ribbers GM, Ricchiuto A, Rubertsson S, Walker A, Wiysonge CS, Zheng P, Bettger JP, Murray CJL, Vos T.
JAMA. 2022 Oct 25;328(16):1604-1615. doi: 10.1001/jama.2022.18931. PMID: 36215063
Neutralisation sensitivity of the SARS-CoV-2 omicron BA.2.75 sublineage.
Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Sander LE, Kurth F, Klein F.
Lancet Infect Dis. 2022 Oct;22(10):1422-1423. doi: 10.1016/S1473-3099(22)00580-1. Epub 2022 Sep 6. PMID: 36084664
Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents.
Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T.
Respir Med. 2022 Oct;202:106968. doi: 10.1016/j.rmed.2022.106968. Epub 2022 Aug 28. PMID: 36081267
Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells.
Dalimot JJ, Klei TRL, Beuger BM, Dikmen Z, Bouwman SAM, Mombo-Ngoma G, Zoleko-Manego R, Ndzebe-Ndoumba WF, Egée S, Kuijpers TW, Grobusch MP, van Bruggen R.
Blood Adv. 2022 Nov 8;6(21):5798-5810. doi: 10.1182/bloodadvances.2021006171. PMID: 35349634
Neuevaluierung der Ribavirintherapie bei Lassafieber. Pharmakokinetik von Ribavirin bei Lassafieber.
Christine J. Kleist , Mirjam Groger
Flugmedizin · Tropenmedizin · Reisemedizin - FTR 2022; 29(05): 205 DOI: 10.1055/a-1909-7904
Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study
Jonas Früh, Andre Fuchs, Tafese Beyene Tufa, Loraine Früh, Zewdu Hurissa, Hans Martin Orth, Johannes Georg Bode, Kirsten Alexandra Eberhardt, Dieter Häussinger, Torsten Feldt
PLoS One . 2021 Feb 4;16(2):e0245496. doi: 10.1371/journal.pone.0245496. eCollection 2021.
Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses
Stephan Schlickeiser, Tatjana Schwarz, Sophie Steiner, Kirsten Wittke, Nabeel Al Besher, Oliver Meyer, Ulrich Kalus, Axel Pruß, Florian Kurth, Thomas Zoller, Martin Witzenrath, Leif Erik Sander, Marcel A Müller, Carmen Scheibenbogen, Hans-Dieter Volk, Christian Drosten, Victor M Corman, Leif G Hanitsch.
Full text links full text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles References MeSH terms Substances Supplementary concepts Related information LinkOut - more resources Front Immunol . 2021 Jan 29;11:628971. doi: 10.3389/fimmu.2020.628971. eCollection 2020.
Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells
Merryn Fraser, Weidong Jing, Stefan Bröer, Florian Kurth, Leif-Erik Sander, Kai Matuschewski, Alexander G. Maier.
PLoS Pathog . 2021 Feb 18;17(2):e1009259. doi: 10.1371/journal.ppat.1009259. eCollection 2021 Feb.
Birth weight, growth, nutritional status and mortality of infants from Lambare´ne´ and Fougamou in Gabon in their first year of life
Rella Zoleko-Manego, Johannes Mischlinger, Jean Claude Dejon-Agobé, Arti Basra, J Rodolphe Mackanga, Daisy Akerey Diop, Ayola Akim Adegnika, Selidji T Agnandji, Bertrand Lell, Peter G Kremsner, Pierre Blaise Matsiegui, Raquel González, Clara Menendez, Michael Ramharter, Ghyslain Mombo-Ngoma.
PLoS One . 2021 Feb 9;16(2):e0246694. doi: 10.1371/journal.pone.0246694. eCollection 2021.
Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG
Kirsten Alexandra Eberhardt, Felix Dewald, Eva Heger, Lutz Gieselmann, Kanika Vanshylla, Maike Wirtz, Franziska Kleipass, Wibke Johannis, Philipp Schommers, Henning Gruell, Karl August Brensing, Roman-Ulrich Müller, Max Augustin, Clara Lehmann, Manuel Koch, Florian Klein, Veronica Di Cristanziano.
Microorganisms . 2021 Mar 31;9(4):733. doi: 10.3390/microorganisms9040733.
Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon
Josiane Honkpéhèdji Y, Romeo Adegbite B, Fréjus Zinsou J, Claude Dejon-Agobé J, Edoa JR, Zoleko Manego R, McCall M, Mbong Ngwese M, Lotola Mougeni F, Mombo-Ngoma G, Ramharter M, Kremsner PG, Lell B, Yazdanbakhsh M, Esen M, Akim Adegnika A.
Trop Med Int Health . 2021 Apr 15. doi: 10.1111/tmi.13591. Online ahead of print.
Less than you'd think-a prospective study on MRSA-colonization in healthy travellers
Tran DT, Winter D, Christner M, Ramharter M, Addo MM, Rolling T, Vinnemeier C, Koch T.
J Travel Med . 2021 Apr 14;28(3):taaa242. doi: 10.1093/jtm/taaa242.
A call to caution when hydroxychloroquine is given to elderly patients with COVID-19.
Gabor JJ, Kreidenweiss A, Weber S, Salama M, Sulyok M, Sulyok Z, Koehne E, Esen M, Kreuels B, Shamsrizi P, Biecker E, Mordmüller B, Berg CP, Fusco S, Köhler C, Kubicka S, Leitlein J, Addo M, Ramharter M, Schwab M, Bissinger AL, Velavan TP, Krishna S, Kremsner PG.
Int J Infect Dis. 2021 Apr 10;106:265-268. doi: 10.1016/j.ijid.2021.04.009. Online ahead of print. PMID: 33848675
Malaria in the Time of COVID-19: Do Not Miss the Real Cause of Illness.
Jochum J, Kreuels B, Tannich E, Huber S, Schulze Zur Wiesch J, Schmiedel S, Ramharter M, Addo MM.
Trop Med Infect Dis. 2021 Mar 26;6(2):40. doi: 10.3390/tropicalmed6020040. PMID: 33810597
Predictive performance of rapid diagnostic tests for falciparum malaria and its modelled impact on integrated community case management of malaria in sub-Saharan African febrile children.
Mischlinger J, Dudek V, Ramharter M.
Clin Infect Dis. 2021 Jan 28:ciaa1942. doi: 10.1093/cid/ciaa1942. Online ahead of print. PMID: 33506270
Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon
amharter M, Agnandji ST, Adegnika AA, Lell B, Mombo-Ngoma G, Grobusch MP, McCall M, Muranaka R, Kreidenweiss A, Velavan TP, Esen M, Schaumburg F, Alabi A, Druml C, Mordmüller B, Köhler C, Kremsner PG.
Wien Klin Wochenschr. 2021 Jan 4:1-9. doi: 10.1007/s00508-020-01794-8. Online ahead of print. PMID: 33398458
COVID-19 Vaccine Acceptance, Barriers and Facilitators among Healthcare Workers in Pakistan
Rehman K, Hakim M, Arif N, Islam SU, Saboor A, Asif M, Ramharter M.
Journal of Infectious Diseases & Therapy, Preprint from Research Square, 19 Apr 2021 DOI: 10.21203/rs.3.rs-431543/v1 PPR: PPR313640
Comparative Assessment of In-House Real-Time PCRs Targeting Enteric Disease-Associated Microsporidia in Human Stool Samples
Tanida, K.; Hahn, A.; Eberhardt, K.A.; Tannich, E.; Landt, O.; Kann, S.; Feldt, T.; Sarfo, F.S.; Di Cristanziano, V.; Frickmann, H.; Loderstädt, U.
Pathogens. 2021; 10(6):656. https://doi.org/10.3390/pathogens10060656
Psychometric properties of the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) in two-year-old Ivorian and Ghanaian children
Dana Barthel, Levente Kriston, Nan Guo, Esther Doris Yao, Koffi Ekissi Jean Armel, Daniel Fordjour, Yasmin Mohammed, Carine Esther Bony Kotchi, Kirsten Alexandra EberhardtORCID Icon, Rebecca Hinz, Stephan Ehrhardt & Carola Bindt
Applied Developmental Science. 2021 Jun 3; https://doi.org/10.1080/10888691.2021.1931216
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Binder M, Loske J, Klasa C, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Völker MT, Müller SD, Liebert UG, Ishaque N, Kaderali L, Sander LE, Drosten C, Laudi S, Eils R, Conrad C, Landmesser U, Lehmann I.
Nat Biotechnol. 2020 Dec 24. doi: 10.1038/s41587-020-00796-1. Online ahead of print.PMID: 33361824
Paediatric formulations of artemisinin-based combination therapies for treating uncomplicated malaria in children.
Bélard S, Ramharter M, Kurth F.
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A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.
Hicks SM, Pohl K, Neeman T, McNamara HA, Parsons KM, He JS, Ali SA, Nazir S, Rowntree LC, Nguyen THO, Kedzierska K, Doolan DL, Vinuesa CG, Cook MC, Coatsworth N, Myles PS, Kurth F, Sander LE, Mann GJ, Gruen RL, George AJ, Gardiner EE, Cockburn IA
J Infect Dis . 2021 Jan 4;223(1):10-14. doi: 10.1093/infdis/jiaa623.
Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021
Tober-Lau P, Schwarz T, Hillus D, Spieckermann J, Helbig ET, Lippert LJ, Thibeault C, Koch W, Bergfeld L, Niemeyer D, Muhlemann B, Conrad C, Kasper S, Munn F, Kunitz F, Jones TC, Suttorp N, Drosten C, Sander LE, Kurth F, Corman VM.
Emerg Infect Dis . 2021 Aug;27(8):2169-2173. doi: 10.3201/eid2708.210887. Epub 2021 Jun 8.
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study
Thibeault C, Muhlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Muller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE, Pa CSG, Corman VM, Kurth F.
Infection . 2021 Aug;49(4):703-714. doi: 10.1007/s15010-021-01594-w. Epub 2021 Apr 22.
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany.
Schwarz T, Tober-Lau P, Hillus D, Helbig ET, Lippert LJ, Thibeault C, Koch W, Landgraf I, Michel J, Bergfeld L, Niemeyer D, Muhlemann B, Conrad C, Dang-Heine C, Kasper S, Munn F, Kappert K, Nitsche A, Tauber R, Schmidt S, Kopankiewicz P, Bias H, Seybold J, von Kalle C, Jones TC, Suttorp N, Drosten C, Sander LE, Corman VM, Kurth F.
Emerg Infect Dis . 2021 Aug;27(8):2174-2178. doi: 10.3201/eid2708.211145. Epub 2021 Jun 8.
SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients.
Schwarz T, Heiss K, Mahendran Y, Casilag F, Kurth F, Sander LE, Wendtner CM, Hoechstetter MA, Muller MA, Sekul R, Drosten C, Stadler V, Corman VM.
Front Immunol . 2021 Mar 23;12:629185. doi: 10.3389/fimmu.2021.629185. eCollection 2021.
Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis.
Schrezenmeier E, Bergfeld L, Hillus D, Lippert JD, Weber U, Tober-Lau P, Landgraf I, Schwarz T, Kappert K, Stefanski AL, Sattler A, Kotsch K, Dorner T, Sander LE, Budde K, Halleck F, Kurth F, Corman VM, Choi M.
Front Immunol . 2021 Jun 30;12:690698. doi: 10.3389/fimmu.2021.690698. eCollection 2021.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Muller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.
Eur Respir J . 2021 Mar 11;57(3):2002384. doi: 10.1183/13993003.02384-2020. Print 2021 Mar.
Ultra-fast proteomics with Scanning SWATH.
Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jurgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mulleder M, Tate S, Ralser M.
Nat Biotechnol . 2021 Jul;39(7):846-854. doi: 10.1038/s41587-021-00860-4. Epub 2021 Mar 25.
Estimating infectiousness throughout SARS-CoV-2 infection course.
Jones TC, Biele G, Muhlemann B, Veith T, Schneider J, Beheim-Schwarzbach J, Bleicker T, Tesch J, Schmidt ML, Sander LE, Kurth F, Menzel P, Schwarzer R, Zuchowski M, Hofmann J, Krumbholz A, Stein A, Edelmann A, Corman VM, Drosten C.
Science . 2021 Jul 9;373(6551):eabi5273. doi: 10.1126/science.abi5273. Epub 2021 May 25.
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.
Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J, Group ECS, Klein F, Kurth F, Corman VM, Sander LE.
Lancet Respir Med . 2021 Aug 12;S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X.
. Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Muhlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Muller MA, Pa C-csg, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F.
Clin Microbiol Infect . 2021 Oct;27(10):1520.e7-1520.e10. doi: 10.1016/j.cmi.2021.06.008. Epub 2021 Jun 15.
Collaborators SA-C-TiES. A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.
Hicks SM, Pohl K, Neeman T, McNamara HA, Parsons KM, He JS, Ali SA, Nazir S, Rowntree LC, Nguyen THO, Kedzierska K, Doolan DL, Vinuesa CG, Cook MC, Coatsworth N, Myles PS, Kurth F, Sander LE, Mann GJ, Gruen RL, George AJ, Gardiner EE, Cockburn IA.
Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells.
Fraser M, Jing W, Broer S, Kurth F, Sander LE, Matuschewski K, Maier AG.
PLoS Pathog . 2021 Feb 18;17(2):e1009259. doi: 10.1371/journal.ppat.1009259. eCollection 2021 Feb.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity.
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glosenkamp C, Muller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hubner RH.
Infection . 2021 Aug;49(4):757-762. doi: 10.1007/s15010-021-01606-9. Epub 2021 Apr 6.
A time-resolved proteomic and prognostic map of COVID-19.
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Rohl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Gruning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glosenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jurgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Muller-Redetzky H, Zoller H, Loffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mulleder M, Sander LE, group P-C-S, Ralser M, Kurth F.
Cell Syst . 2021 Aug 18;12(8):780-794.e7. doi: 10.1016/j.cels.2021.05.005. Epub 2021 Jun 14.
Echocardiographic Evaluation of Right Ventricular (RV) Performance over Time in COVID-19-Associated ARDS-A Prospective Observational Study.
Asgarpur G, Treskatsch S, Angermair S, Danassis M, Nothnagel AM, Toepper C, Trauzeddel RF, Nordine M, Heeschen J, Al-Chehadeh A, Landmesser U, Sander LE, Kurth F, Berger C.
J Clin Med . 2021 May 1;10(9):1944. doi: 10.3390/jcm10091944.
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.
Science . 2021 Oct 8;374(6564):eabh1823. doi: 10.1126/science.abh1823. Epub 2021 Oct 8.
Hookworm infection in returning travellers and migrants: a 10-year case series at a German center for tropical medicine.
Saffar F, Kurth F, Tannich E, Ramharter M, Jochum J.
J Travel Med . 2021 Jan 6;28(1):taaa183. doi: 10.1093/jtm/taaa183.
Selbst eingeschätzte medizinische Versorgung im Verlauf der SARS-CoV-2-Pandemie in Deutschland: Ergebnisse der COSMO-Studie.
Heidemann C, Paprott R, Huebl L, Scheidt-Nave C, Reitzle L.
Postponed Dental Visits during the COVID-19 Pandemic and their Correlates. Evidence from the Nationally Representative COVID-19 Snapshot Monitoring in Germany (COSMO).
Hajek A, De Bock F, Huebl L, Kretzler B, König HH.
Healthcare (Basel) . 2021 Jan 5;9(1):50. doi: 10.3390/healthcare9010050.
Physical Activity during COVID-19 in German Adults: Analyses in the COVID-19 Snapshot Monitoring Study (COSMO).
Maertl T, De Bock F, Huebl L, Oberhauser C, Coenen M, Jung-Sievers C, On Behalf Of The Cosmo Study Team.
Int J Environ Res Public Health . 2021 Jan 9;18(2):507. doi: 10.3390/ijerph18020507.
Psittacosis in a traveller.
Veletzky L, Huebl L, Schulze zur Wiesch J, Schmiedel S.
J Travel Med . 2021 Aug 27;28(6):taab062. doi: 10.1093/jtm/taab062.
Recurrent Swelling and Microfilaremia Caused by Dirofilaria repens Infection after Travel to India.
Huebl L, Tappe D, Giese M, Mempel S, Tannich E, Kreuels B, Ramharter M, Veletzky L, Jochum J.
Emerg Infect Dis . 2021 Jun;27(6):1701-1704. doi: 10.3201/eid2706.210592.
Perceived Access to Health Care Services and Relevance of Telemedicine during the COVID-19 Pandemic in Germany.
Reitzle L, Schmidt C, Färber F, Huebl L, Wieler LH, Ziese T, Heidemann C.
Int J Environ Res Public Health . 2021 Jul 19;18(14):7661. doi: 10.3390/ijerph18147661.
Determinants of Postponed Cancer Screening During the COVID-19 Pandemic: Evidence from the Nationally Representative COVID-19 Snapshot Monitoring in Germany (COSMO).
Hajek A, De Bock F, Huebl L, Kretzler B, König HH.
Risk Manag Healthc Policy . 2021 Jul 14;14:3003-3011. doi: 10.2147/RMHP.S297326. eCollection 2021.
Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy.
Mischlinger J, Manego RZ, Mombo-Ngoma G, Ekoka Mbassi D, Hackbarth N, Ekoka Mbassi FA, Davi SD, Kreuzmair R, Veletzky L, Hergeth J, Ndoumba WN, Pitzinger P, Groger M, Matsiegui PB, Adegnika AA, Agnandji ST, Lell B, Ramharter M.
PLoS Negl Trop Dis . 2021 Aug 16;15(8):e0009623. doi: 10.1371/journal.pntd.0009623. eCollection 2021 Aug.
Quantification of the Proportion of Unfavorable Clinical Outcomes among Imported Malaria Patients According to the Degree of Semi-Immunity on Population Level: An Ecological Study.
Nordmann T, Davi SD, Ramharter M, Mischlinger J.
Am J Trop Med Hyg . 2021 Jun 14;105(2):477-479. doi: 10.4269/ajtmh.21-0196.
Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study.
Früh J, Fuchs A, Tufa TB, Früh L, Hurissa Z, Orth HM, Bode JG, Eberhardt KA, Häussinger D, Feldt T.
PLoS One . 2021 Feb 4;16(2):e0245496. doi: 10.1371/journal.pone.0245496. eCollection 2021.
Detection of SARS-CoV-2 viremia before onset of COVID-19 symptoms in an allo-transplanted patient with acute leukemia.
Di Cristanziano V*, Meyer-Schwickerath C*, Eberhardt KA*, Rybniker J, Heger E, Knops E, Hallek M, Klein F, Holtick U, Jung N.
Bone Marrow Transplant . 2021 Mar;56(3):716-719. doi: 10.1038/s41409-020-01059-y. Epub 2020 Sep 18.
Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans.
Vanshylla K, Di Cristanziano V, Kleipass F, Dewald F, Schommers P, Gieselmann L, Gruell H, Schlotz M, Ercanoglu MS, Stumpf R, Mayer P, Zehner M, Heger E, Johannis W, Horn C, Suárez I, Jung N, Salomon S, Eberhardt KA, Gathof B, Fätkenheuer G, Pfeifer N, Eggeling R, Augustin M, Lehmann C, Klein F.
Cell Host Microbe . 2021 Jun 9;29(6):917-929.e4. doi: 10.1016/j.chom.2021.04.015. Epub 2021 May 3.
Analysis of Human Gut Microbiota Composition Associated to the Presence of Commensal and Pathogen Microorganisms in Côte d’Ivoire.
Veronica Di Cristanziano; Fedja Farowski; Federica Berrilli; Maristella Santoro; David Di Cave; Christophe Glé; Martin Daeumer; Alexander Thielen; Maike Wirtz; Rolf Kaiser; Kirsten Alexandra Eberhardt; Maria J. G. T. Vehreschild; Rossella D’Alfonso.
Microorganisms . 2021 Aug 18;9(8):1763. doi: 10.3390/microorganisms9081763.
Comparison of Two Real-time PCR Assays Targeting Ribosomal Sequences for the Identification of Cystoisospora belli in Human Stool Samples.
Martin Blohm; Andreas Hahn; Ralf Matthias Hagen; Kirsten Alexandra Eberhardt; Holger Rohde; Gérard Leboulle; Torsten Feldt; Fred Stephen Sarfo; Veronica Di Cristanziano; Hagen Frickmann; Ulrike Loderstädt.
Pathogens . 2021 Aug 19;10(8):1053. doi: 10.3390/pathogens10081053.
Intestinal colonization with Tropheryma whipplei – Clinical and immunological implications for HIV positive adults in Ghana.
Kirsten Alexandra Eberhardt; Fred Stephen Sarfo; Eva-Maria Klupp; Albert Dompreh; Veronica Di Cristanziano; Edmund Osei Kuffour; Richard Boateng; Betty Norman; Richard Odame Phillips; Martin Aepfelbacher; Torsten Feldt.
Microorganisms . 2021 Aug 22;9(8):1781. doi: 10.3390/microorganisms9081781.
Polymicrobial enteric infections in African infants with diarrhoea-results from a longitudinal prospective case-control study.
Melina Heinemann, Cornelia Strauchs, Marc Lütgehetmann, Martin Aepfelbacher, Eva-Maria Klupp, Ellis Owusu-Dabo, Thierry Rolling, Jakob P Cramer, Christof D Vinnemeier.
Clin Microbiol Infect . 2021 Apr 1;S1198-743X(21)00155-5. doi: 10.1016/j.cmi.2021.03.020.
Reisevorbereitungen für Patienten mit Psoriasis unter Immunsuppression.
Brigitte Stephan, Jörg Tittelbach, Silja Bühler.
J Dtsch Dermatol Ges . 2021 Feb;19(2):197-208. doi: 10.1111/ddg.14377_g.
TOURIST2 - Tracking of urgent risks in swiss travellers to the 6 main travel destinations - Feasibility and ethical considerations of a smartphone application-based study.
Vasiliki Baroutsou , Christoph Hatz, Ulf Blanke, Sarah R Haile, Jan Fehr, Andreas Neumayr, Milo A Puhan , Silja Bühler.
Travel Med Infect Dis . Jan-Feb 2021;39:101912. doi: 10.1016/j.tmaid.2020.101912. Epub 2020 Nov 7.
Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.
Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M, CANTAM study group.
PLoS Med . 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669. eCollection 2021 Jun.
Impact of dose, duration and immune status on efficacy of ultrashort telacebec regimens in mouse models of Buruli ulcer.
Oliver Komm, Deepak V. Almeida, Paul J. Converse, Till F. Omansen, Eric L. Nuermberger.
Antimicrob Agents Chemother . 2021 Oct 18;65(11):e0141821. doi: 10.1128/AAC.01418-21. Epub 2021 Aug 30.
Recurrent Swelling and Microfilaremia Caused by Dirofilaria repens Infection after Travel to India.
Huebl L, Tappe D, Giese M, Mempel S, Tannich E, Kreuels B, Ramharter M, Veletzky L, Jochum J.
Emerg Infect Dis . 2021 Jun;27(6):1701-1704. doi: 10.3201/eid2706.210592.
Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19.
Malsy J and Veletzky L, et al.
Clin Infect Dis . 2020 Oct 26;ciaa1637. doi: 10.1093/cid/ciaa1637. Online ahead of print.
Negative SARS-CoV-2 PCR or rapid antigen test result and the subsequent risk of being infectious: a mathematical simulation study.
Krumkamp R, Kreuels B, Jaeger VK, May J, Mikolajczyk R, Karch A.
BMC Med Res Methodol . 2021 Aug 10;21(1):165. doi: 10.1186/s12874-021-01361-3.
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients.
Velavan TP, Kuk S, Linh LTK, Lamsfus Calle C, Lalremruata A, Pallerla SR, Kreidenweiss A, Held J, Esen M, Gabor J, Neurohr EM, Shamsrizi P, Fathi A, Biecker E, Berg CP, Ramharter M, Addo MM, Kreuels B, Kremsner PG.
Sci Rep . 2021 Jul 14;11(1):14471. doi: 10.1038/s41598-021-93950-x.
Risk factors for and management of metronidazole-refractory giardiasis in international travellers: A retrospective analysis.
Peters TE, Kreuels B, Addo MM, Tannich E, Rothe C.
Travel Med Infect Dis . Sep-Oct 2021;43:102090. doi: 10.1016/j.tmaid.2021.102090. Epub 2021 Jun 1.
Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020.
Brehm TT, Heyer A, Roedl K, Jarczak D, Nierhaus A, Nentwich MF, van der Meirschen M, Schultze A, Christner M, Fiedler W, Kröger N, Huber TB, Klose H, Sterneck M, Jordan S, Kreuels B, Schmiedel S, Addo MM, Huber S, Lohse AW, Kluge S, Schulze Zur Wiesch J.
J Clin Med . 2021 May 24;10(11):2274. doi: 10.3390/jcm10112274.
Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi.
Stockdale AJ, Silungwe NM, Shawa IT, Kreuels B, Gordon MA, Geretti AM.
BMC Infect Dis . 2021 May 27;21(1):487. doi: 10.1186/s12879-021-06134-3.
Common virulence gene expression in adult first-time infected malaria patients and severe cases.
Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JA, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, Otto TD, Lavstsen T, Gilberger TW, Duffy MF, Bachmann A.
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Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.
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Late presentation of hepatocellular carcinoma highlights the need for a public health programme to eliminate hepatitis B.
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PLoS One . 2021 Mar 4;16(3):e0247646. doi: 10.1371/journal.pone.0247646. eCollection 2021.
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
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An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany
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The Supposedly Innocuous Eye Worm: Or, What Could Make You Put Chili in Your Eye?
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Am J Trop Med Hyg . 2021 Sep 13;105(6):1448-1449. doi: 10.4269/ajtmh.21-0319.
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
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TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature.
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The Lancet Infectious Diseases. 2020 Jun 22;https://doi.org/10.1016/S1473-3099(20)30256-5
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The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data.
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BMC Med. 2020 Feb 25;18(1):47. PMID: 32098634 PMCID: PMC7043031 DOI: 10.1186/s12916-020-1494-3
Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
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BMJ Open. 2020 Apr 16;10(4):e036936. doi: 10.1136/bmjopen-2020-036936.
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
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Measles, Vaccines, and Types of Perception Bias in Public Debates.
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Rabies exposure in travellers to Asia, the Middle East, Africa, South and Central America-a German Airport study.
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Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle.
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Integrated safety analysis: Frequency of urinary tract infections in patients with psoriasis treated with ixekizumab.
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Diagnostic Techniques of Soil-Transmitted Helminths: Impact on Control Measures.
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Evaluating case definitions for Ebola virus disease.
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Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings.
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An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany
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A case for adoption of continuous albendazole treatment regimen for human echinococcal infections.
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Traveling into the abyss: risk perception of German travelers at the onset of the COVID-19 pandemic.
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Travel patterns, risk behaviour and health problems of travellers with rheumatic diseases compared to controls: A multi-centre, observational study.
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Safety and immunogenicity of a primary yellow fever vaccination under low-dose methotrexate therapy-a prospective multi-centre pilot study1.
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The COVID-19 pandemic offers a key moment to reflect on travel medicine practice.
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Risk estimation for air travel-induced malaria transmission in central Europe - A mathematical modelling study.
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The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.
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Detection of SARS-CoV-2 viremia before onset of COVID-19 symptoms in an allo-transplanted patient with acute leukemia.
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A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon.
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The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound
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Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections.
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Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy.
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Case Report: Acute Vision Loss in a Young Returning Traveler with Dengue Fever.
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Treatment and re-treatment results of HCV patients in the DAA era.
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Describing nearly two decades of Chagas disease in Germany and the lessons learned: a retrospective study on screening, detection, diagnosis, and treatment of Trypanosoma cruzi infection from 2000 - 2018.
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A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana.
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African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
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Immediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study).
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Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Tannich E, Mombo-Ngoma G, Mordmüller B, Ramharter M.
J Infect Dis. 2018 May 25. doi: 10.1093/infdis/jiy319. [Epub ahead of print]
Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts.
Lötsch F, Mombo-Ngoma G, Mischlinger J, Groger M, Veletzky L, Adegnika AA, Lell B, Agnandji ST, Bouyou-Akotet M, Obermüller M, Wassermann M, Schneider R, Auer H, Ramharter M.
Am J Trop Med Hyg. 2018 Jul;99(1):97-101. doi: 10.4269/ajtmh.17-0955. Epub 2018 May 17.
Dalbavancin as primary and sequential treatment for Gram-positive infective endocarditis: 2-Year Experience at the General Hospital of Vienna.
Tobudic S, Forstner C, Burgmann H, Lagler H, Ramharter M, Steininger C, Vossen MG, Winkler S, Thalhammer F.
Clin Infect Dis. 2018 Apr 5. doi: 10.1093/cid/ciy279. [Epub ahead of print]
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.
Hede MS, Fjelstrup S, Lötsch F, Zoleko RM, Klicpera A, Groger M, Mischlinger J, Endame L, Veletzky L, Neher R, Simonsen AKW, Petersen E, Mombo-Ngoma G, Stougaard M, Ho YP, Labouriau R, Ramharter M, Knudsen BR.
Sci Rep. 2018 Mar 7;8(1):4122. doi: 10.1038/s41598-018-22378-7.
Behavioural and clinical predictors for Loiasis.
Mischlinger J, Veletzky L, Tazemda-Kuitsouc GB, Pitzinger P, Matsegui PB, Gmeiner M, Lagler H, Gebru T, Held J, Mordmüller B, Ramharter M.
J Glob Health. 2018 Jun;8(1):010413. doi: 10.7189/jogh.08.010413.
Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection.
Veletzky L, Groger M, Lagler H, Walochnik J, Auer H, Fuehrer HP, Ramharter M.
Malar J. 2018 Feb 9;17(1):78. doi: 10.1186/s12936-018-2226-4.
Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon.
Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Zoleko-Manego R, Endamne L, Klicpera A, Kim J, Nguyen T, Flohr L, Remppis J, Matsiegui PB, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Ramharter M.
Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01758-17. doi: 10.1128/AAC.01758-17. Print 2018 Mar.
Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon.
Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Joerg M, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG.
Clin Infect Dis. 2017 Dec 26. doi: 10.1093/cid/cix1122. [Epub ahead of print]
Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial.
Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG.
PLoS Med. 2017 Oct 6;14(10):e1002402. doi: 10.1371/journal.pmed.1002402. eCollection 2017 Oct.
Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing.
Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Bélard S, Mombo-Ngoma G, Ramharter M, Kremsner PG, Mordmüller B, Held J.
Malar J. 2017 Oct 3;16(1):398. doi: 10.1186/s12936-017-2044-0.
FDG-PET/MRI in alveolar echinococcosis.
Lötsch F, Waneck F, Auer H, Kaczirek K, Karanikas G, Ramharter M.
Int J Infect Dis. 2017 Nov;64:67-68. doi: 10.1016/j.ijid.2017.09.006. Epub 2017 Sep 19.
Dalbavancin for outpatient parenteral antimicrobial therapy of skin and soft tissue infections in a returning traveller : Proposal for novel treatment indications.
Mischlinger J, Lagler H, Harrison N, Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):642-645. doi: 10.1007/s00508-017-1243-6. Epub 2017 Aug 3.
Prof. Walther H. Wernsdorfer (1928-2016).
Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):650-651. doi: 10.1007/s00508-017-1236-5. Epub 2017 Jul 25.
Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.
Ndam NT, Mbuba E, González R, Cisteró P, Kariuki S, Sevene E, Rupérez M, Fonseca AM, Vala A, Maculuve S, Jiménez A, Quintó L, Ouma P, Ramharter M, Aponte JJ, Nhacolo A, Massougbodji A, Briand V, Kremsner PG, Mombo-Ngoma G, Desai M, Macete E, Cot M, Menéndez C, Mayor A.
BMC Med. 2017 Jul 17;15(1):130. doi: 10.1186/s12916-017-0893-6.
Direct detection of Anaplasma phagocytophilum by polymerase chain reaction followed by electrospray ionization mass spectrometry from human blood.
Lagler H, Harrison N, Kussmann M, Obermüller M, Burgmann H, Makristathis A, Ramharter M.
Int J Infect Dis. 2017 Jul;60:61-63. doi: 10.1016/j.ijid.2017.05.006. Epub 2017 May 16.
Severe malaria in Europe: an 8-year multi-centre observational study.
Kurth F, Develoux M, Mechain M, Malvy D, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Lingscheid T, Kern P, Kapaun A, da Cunha JS, Pongratz P, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T.
Malar J. 2017 Jan 31;16(1):57. doi: 10.1186/s12936-016-1673-z.
Progressive Perforation of the Nasal Septum Due to Leishmania major: A Case of Mucosal Leishmaniasis in a Traveler.
Harrison N, Walochnik J, Ramsebner R, Veletzky L, Lagler H, Ramharter M.
Am J Trop Med Hyg. 2017 Mar;96(3):653-655. doi: 10.4269/ajtmh.16-0809. Epub 2017 Apr 6.
Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon.
Manego RZ, Mombo-Ngoma G, Witte M, Held J, Gmeiner M, Gebru T, Tazemda B, Mischlinger J, Groger M, Lell B, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Ramharter M, Matsiegui PB.
BMC Public Health. 2017 Jan 28;17(1):130. doi: 10.1186/s12889-017-4045-x.
Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function.
Schuster C, Binder C, Strassl R, Aichelburg MC, Blackwell E, Pavo N, Ramharter M, Hülsmann M, Grabmeier-Pfistershammer K, Rieger A, Goliasch G.
AIDS. 2017 Jan 28;31(3):395-400. doi: 10.1097/QAD.0000000000001350.
Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon.
Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, Agobe JC, Lell B, Matsiegui PB, Gonzales R, Agnandji ST, Yazdanbakhsh M, Menendez C, Kremsner PG, Adegnika AA, Ramharter M.
Int J Parasitol. 2017 Jan;47(1):69-74. doi: 10.1016/j.ijpara.2016.11.001. Epub 2016 Dec 18.
Zika virus-induced itching rash in a returning traveller from Brazil.
Veletzky L, Knafl D, Schuster C, Aberle SW, Stiasny K, Ramharter M, Lagler H.
Int J Infect Dis. 2017 Jan;54:13-14. doi: 10.1016/j.ijid.2016.11.004. Epub 2016 Nov 7
Seroprevalence of Toxocara spp. in a rural population in Central African Gabon.
Lötsch F, Obermüller M, Mischlinger J, Mombo-Ngoma G, Groger M, Adegnika AA, Agnandji ST, Schneider R, Auer H, Ramharter M.
Parasitol Int. 2016 Dec;65(6 Pt A):632-634. doi: 10.1016/j.parint.2016.09.001. Epub 2016 Sep 2.
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania.
Harrison N, Burgmann H, Forstner C, Ramharter M, Széll M, Schötta AM, Stanek G, Markowicz M.
Wien Klin Wochenschr. 2016 Aug;128(15-16):602-5. doi: 10.1007/s00508-016-1047-0. Epub 2016 Aug 3.
Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study.
Mombo-Ngoma G, Mackanga JR, González R, Ouedraogo S, Kakolwa MA, Manego RZ, Basra A, Rupérez M, Cot M, Kabanywany AM, Matsiegui PB, Agnandji ST, Vala A, Massougbodji A, Abdulla S, Adegnika AA, Sevene E, Macete E, Yazdanbakhsh M, Kremsner PG, Aponte JJ, Menéndez C, Ramharter M.
BMJ Open. 2016 Jun 29;6(6):e011783. doi: 10.1136/bmjopen-2016-011783.
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
Single dose treatment of malaria - current status and perspectives.
Mischlinger J, Agnandji ST, Ramharter M.
Expert Rev Anti Infect Ther. 2016 Jul;14(7):669-78. doi: 10.1080/14787210.2016.1192462. Epub 2016 Jun 7.
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data.
WWARN Gametocyte Study Group.
BMC Med. 2016 May 24;14:79. doi: 10.1186/s12916-016-0621-7.
The first meeting of the European Register of Cystic Echinococcosis (ERCE).
Rossi P, Tamarozzi F, Galati F, Pozio E, Akhan O, Cretu CM, Vutova K, Siles-Lucas M, Brunetti E, Casulli A; HERACLES extended network.
Parasit Vectors. 2016 Apr 28;9:243. doi: 10.1186/s13071-016-1532-3.
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data.
Lötsch F, Naderer J, Skuhala T, Groger M, Auer H, Kaczirek K, Waneck F, Ramharter M.
Parasitol Res. 2016 Aug;115(8):2995-3001. doi: 10.1007/s00436-016-5054-x. Epub 2016 Apr 16.
Effect of mild medical hypothermia on in vitro growth of Plasmodium falciparum and the activity of anti-malarial drugs.
Rehman K, Sauerzopf U, Veletzky L, Lötsch F, Groger M, Ramharter M.
Malar J. 2016 Mar 15;15:162. doi: 10.1186/s12936-016-1215-8.
Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study.
Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, Kakolwa MA, Vala A, Accrombessi M, Briand V, Aponte JJ, Manego Zoleko R, Adegnika AA, Cot M, Kremsner PG, Massougbodji A, Abdulla S, Ramharter M, Macete E, Menéndez C.
PLoS Med. 2016 Feb 23;13(2):e1001964. doi: 10.1371/journal.pmed.1001964. eCollection 2016 Feb.
Anaplasmataceae-Specific PCR for Diagnosis and Therapeutic Guidance for Symptomatic Neoehrlichiosis in Immunocompetent Host.
Schwameis M, Auer J, Mitteregger D, Simonitsch-Klupp I, Ramharter M, Burgmann H, Lagler H.
Emerg Infect Dis. 2016 Feb;22(2):281-4. doi: 10.3201/eid2202.141762.
Alterations of blood coagulation in controlled human malaria infection.
Riedl J, Mordmüller B, Koder S, Pabinger I, Kremsner PG, Hoffman SL, Ramharter M, Ay C.
Malar J. 2016 Jan 7;15:15. doi: 10.1186/s12936-015-1079-3.
Imported malaria in pregnant women: A retrospective pooled analysis.
Käser AK, Arguin PM, Chiodini PL, Smith V, Delmont J, Jiménez BC, Färnert A, Kimura M, Ramharter M, Grobusch MP, Schlagenhauf P.
Travel Med Infect Dis. 2015 Jul-Aug;13(4):300-10. doi: 10.1016/j.tmaid.2015.06.011. Epub 2015 Jul 9.
Activity of antimicrobial drugs against bacterial pathogens under mild hypothermic conditions.
Wallmüller C, Herold B, Sterz F, Makristathis A, Ramharter M.
Am J Emerg Med. 2015 Oct;33(10):1445-8. doi: 10.1016/j.ajem.2015.07.005. Epub 2015 Jul 4.
Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns--A cross-sectional delivery survey in Central Gabon.
Capan-Melser M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Manego-Zoleko R, Würbel H, Lötsch F, Groger M, Skoll M, Schwing J, Schipulle U, Matsiegui PB, González R, Menendez C, Kremsner PG, Adegnika AA, Agnandji ST, Ramharter M.
Int J Infect Dis. 2015 Oct;39:16-9. doi: 10.1016/j.ijid.2015.08.004. Epub 2015 Aug 10.
Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study.
Kurth F, Develoux M, Mechain M, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Pongratz P, Kern P, Saraiva da Cunha J, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T; TropNet Severe Malaria Investigator Group.
Clin Infect Dis. 2015 Nov 1;61(9):1441-4. doi: 10.1093/cid/civ575. Epub 2015 Jul 17.
Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy.
Sicuri E, Fernandes S, Macete E, González R, Mombo-Ngoma G, Massougbodgi A, Abdulla S, Kuwawenaruwa A, Katana A, Desai M, Cot M, Ramharter M, Kremsner P, Slustker L, Aponte J, Hanson K, Menéndez C.
PLoS One. 2015 Apr 27;10(4):e0125072. doi: 10.1371/journal.pone.0125072. eCollection 2015.
Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine.
Capan-Melser M, Mombo Ngoma G, Akerey-Diop D, Basra A, Würbel H, Groger M, Mackanga JR, Zoleko-Manego R, Schipulle U, Schwing J, Lötsch F, Rehman K, Matsiegui PB, Agnandji ST, Adegnika AA, Bélard S, González R, Kremsner PG, Menendez C, Ramharter M.
J Antimicrob Chemother. 2015;70(6):1898-902. doi: 10.1093/jac/dkv041. Epub 2015 Feb 25.
Loa loa Infection in Pregnant Women, Gabon.
Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, Lötsch F, Yazdanbakhsh M, González R, Menendez C, Mabika B, Matsiegui PB, Kremsner PG, Ramharter M.
Emerg Infect Dis. 2015 May;21(5):899a-901. doi: 10.3201/eid2105.141471.
Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria.
Lötsch F, Auer-Hackenberg L, Groger M, Rehman K, Morrison V, Holmes E, Parveen S, Plumpton C, Clyne W, de Geest S, Dobbels F, Vrijens B, Kardas P, Hughes D, Ramharter M.
Wien Klin Wochenschr. 2015 May;127(9-10):379-84. doi: 10.1007/s00508-015-0782-y. Epub 2015 Apr 24.
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.
WWARN Parasite Clearance Study Group, Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D'Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA.
Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.
Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.
Agnandji ST, Fernandes JF, Bache EB, Ramharter M.
Future Microbiol. 2015;10(10):1553-78. doi: 10.2217/fmb.15.90. Epub 2015 Oct 6.
Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.
Belard S, Toepfner N, Capan-Melser M, Mombo-Ngoma G, Zoleko-Manego R, Groger M, Matsiegui PB, Agnandji ST, Adegnika AA, González R, Kremsner PG, Menendez C, Ramharter M, Berner R.
Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.
Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease.
Knafl D, Lötsch F, Burgmann H, Goliasch G, Poeppl W, Ramharter M, Thalhammer F, Schuster C
Case Rep Infect Dis. 2015;2015:317260. doi: 10.1155/2015/317260. Epub 2015 Oct 21.
Case report: spontaneous rupture of spleen in patient with Plasmodium ovale malaria.
Lemmerer R, Unger M, Voßen M, Forstner C, Jalili A, Starzengruber P, Werzowa J, Ramharter M, Winkler S, Thalhammer F.
Wien Klin Wochenschr. 2016 Jan;128(1-2):74-7. doi: 10.1007/s00508-015-0888-2. Epub 2015 Nov 5.
Neither Single nor a Combination of Routine Laboratory Parameters can Discriminate between Gram-positive and Gram-negative Bacteremia.
Ratzinger F, Dedeyan M, Rammerstorfer M, Perkmann T, Burgmann H, Makristathis A, Dorffner G, Loetsch F, Blacky A, Ramharter M.
Sci Rep. 2015 Nov 2;5:16008. doi: 10.1038/srep16008.
Population Pharmacokinetics of Pyronaridine in Pediatric Malaria Patients.
Ayyoub A, Methaneethorn J, Ramharter M, Djimde AA, Tekete M, Duparc S, Borghini-Fuhrer I, Shin JS, Fleckenstein L.
Antimicrob Agents Chemother. 2015 Dec 14;60(3):1450-8. doi: 10.1128/AAC.02004-15.
Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana.
Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Oteng-Seifah EE, Bedu-Addo G, Phillips RO, Norman B, Burchard G, Feldt T.
PLoS One. 2015 Nov 24;10(11):e0143388. doi: 10.1371/journal.pone.0143388. eCollection 2015.
Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Eberhardt KA, Sarfo FS, Dompreh A, Kuffour EO, Geldmacher C, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Bedu-Addo G, Phillips RO, Norman B, Burchard GD, Feldt T.
Clin Infect Dis. 2015 Nov 15;61(10):1615-23. doi: 10.1093/cid/civ577. Epub 2015 Jul 20.
Group B Streptococci serotype distribution in pregnant women in Ghana: assessment of potential coverage through future vaccines.
Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y, Rolling T, Dekker D, Adu-Sarkodie Y, Eberhardt KA, May J, Cramer JP.
Trop Med Int Health. 2015 Nov;20(11):1516-1524. doi: 10.1111/tmi.12589.
CCN1 mutation is associated with atrial septal defect.
Perrot A, Schmitt KR, Roth EM, Stiller B, Posch MG, Browne EN, Timmann C, Horstmann RD, Berger F, Özcelik C.
Pediatr Cardiol. 2015 Feb;36(2):295-9. doi: 10.1007/s00246-014-1001-8. Epub 2014 Aug 19.
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