Research

Arbeitgruppe: Department of Clinical Trials in Tropical Medicine
Department of Clinical Trials in Tropical Medicine

Overview

Clinically relevant aspects of infectious diseases in the tropics and research related to travel medicine are the main focus of our working group. With the aim to improve treatment and prevention options, we are actively involved in basic and clinical research projects together with partners from different parts of the world.

Research Projects


PAIRR und SAFARI: GHPP+ - Build capacity to rapidly halt Lassa fever outbreaks and develop medical countermeasures in Nigeria

Lassa fever has been put on the list of diseases with urgent R & D needs by WHO, as there are no vaccinations or safe treatments. The case mortality is 30%. The project will build capacity in Nigeria to rapidly halt Lassa fever outbreaks and develop medical countermeasures for Lassa fever disorders. The aim is to promptly sequence the circulating viral strains in a Lassa fever outbreak to detect chains of infection and reduce the outbreak faster. Another goal is to test existing and new therapeutic options in humans.

PAIRR: A prospective observational study on pharmacokinetic properties routine clinical Ribavirin treatment in Lassa fever patients at the Irrua Specialist Teaching Hospital in Nigeria

SAFARI: Pharmacokinetics, tolerability and safety of favipiravir alone and in combination with ribavirin for the treatment of Lassa fever: A randomized controlled open label phase II clinical trial

 

 

 


TROPICSAFE - MEDICAL TRANSPORT OF PATIENTS WITH TROPICAL DISEASES IN SAFE CONDITIONS

The project will create an harmonized training program across Europe, allowing health professionals to perform with full guarantees of safety and health the activities of sanitary transport service.

The sanitary transport service is a dangerous task when professionals have to deal with patients suffering contagious diseases. Nowadays there are several protocols to manage the tropical diseases, but health professionals are demanding specific guidelines and more practical training material and with an homogenous criteria.


Moreover, the creation of the Schengen Area and the suppression of internal borders in the EU make necessary common policies and procedures to face any potential outbreak of virus through transnational actions.

The TROPICSAFE project aims to develop an homogeneous training protocol at European level focused on patient transport professionals with normalized guidelines for a proper and safely transfer of patients with tropical diseases.


This training will be published in an Open Online Learning Platform. The training will include audiovisual support such videos, images and graphics in order to better demonstrate the safety procedures the professionals should follow, completed with a questions & answers tests to evaluate the training process, and translated to the languages of the consortium.

The partnership is composed of five institutions who know perfectly the sector in their countries, and represent the interests of workers, health professionals and trainers:

  • Bernhard Nocht Institute for Tropical Medicine, Germany
  • SGS TECNOS, Spain
  • Murray Ambulance Service Ltd., Ireland
  • Biedriba Eurofortis, Latvia
  • ANEA - Spanish Federation of Ambulances, Spain

The project is co-funded by the EU's ERASMUS+ program.

ASAAP (ArteSunate+Amodiaquine+Atovaquone-Proquanil) - pediatric malaria treatment study

ASAAP leads the way in assessing the viability of a triple therapy antimalarial via a multicenter clinical trial. Triple therapy is expected to significantly slow down the rate at which resistance of malaria parasites to medication develops.

Seven reputable institutions across Sub-Saharan Africa, Germany, and France have come together to run the project ASAAP - Clinical evaluation of ArteSunate+Amodiaquine+Atovaquone-Proguanil tri-therapy for malaria treatment in African children. ASAAP is a 48-month-long multicenter clinical trial, coordinated by the Kumasi Center for Collaborative Research in Tropical Medicine (KCCR). 
 
ASAAP’s main objective is to test a new combination of three drugs for how well they work for children and how safe and child-friendly they are. It is hoped that ASAAP will lead to the development of one of the first fixed-dose antimalarial tri-therapies aimed at slowing down resistance to malaria medicines, as well as the risk of mosquitoes passing malaria from one person to another. Over the next 4 years, ASAAP will use its network to develop a platform for clinical trials, entomology and molecular biology in Benin, Ghana, Mali, Gabon and Burkina Faso.

Through the support of EDCTP/EU funding and BMBF, the project is being led and coordinated by Dr. Oumou Maiga-Ascofaré of the BNITM in Germany and the KCCR in Kumasi, Ghana under the authority of the Kwame Nkrumah University of Science and Technology (KNUST), in collaboration with:

  • Dr. Jerome Clain and Dr. Michel Cot at MERIT (Paris); and Dr. Anna Cohuet at MIVEGEC (Montpellier) from the Institut de Recherche pour le Développement (IRD) in France
  • Prof. Abdoulaye Djimdé from the Université des Sciences, des Techniques et des Technologies de Bamako (USTTB) in Bamako in Mali
  • Prof. Achille Massougbodji from the Institut de Recherche Clinique du Bénin (IRCB) in Abomey-Calavi, Benin
  • Dr. Ghyslain Mombo Ngoma from the Center de Recherches Médicales de Lambaréné (CERMEL) in Lambaréné, Gabon
  • Dr. Serge Yerbanga from the Institut des Sciences et Techniques (INSTech) in BoboDioulasso, Burkina Faso
  • Prof. Jürgen May and Prof. Michael Ramharter from the Bernhard-Nocht-Institut für Tropenmedizin (BNITM) in Hamburg, Germany
  • Dr. John Amuasi from KCCR and the department of Global Health at the KNUST School of Public Health in Kumasi, Ghana.

ASAAP is funded by EDCTP and the German Federal Ministry for Education and Research (BMBF). EDCTP invested EUR 7.6 million in the project.


MAMAH

Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV infected women. In Africa, at least one million pregnancies are co-infected with malaria and HIV annually. The interaction between the two infections is particularly deleterious in pregnancy, leading to increased risk of malaria and HIV viral load, which may increase the frequency of mother to child transmission of HIV (MTCTHIV).

Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-uninfected women but it is contraindicated in those HIV-infected on cotrimoxazole prophylaxis (CTXp) due to potential adverse effects. A recent EDCTP-funded trial showed that although an effective antimalarial (mefloquine) added to CTXp and long-lasting insecticide treated nets (LLITNs) in HIV-infected pregnant women improves malaria prevention and maternal health, it was not well tolerated and it was associated with an increase in HIV viral load at delivery and a two-fold increased risk of MTCT-HIV. Thus, this highlights the need to find alternative drugs with better tolerability and safety profile to prevent malaria in this vulnerable group and to further study the pharmacological interactions between antimalarial and antiretroviral (ARV) drugs.

Dihydroartemisinin-piperaquine (DHA-PPQ), has been shown to improve antimalarial protection in HIV-uninfected women constituting the most promising candidate for IPTp in HIV-infected pregnant women. However, there is limited information on the pharmacokinetics of DHA-PPQ with concomitant use of ARV drugs and CTX.

Objective:

A randomized double blind placebo controlled trial to evaluate the safety and efficacy of DHA-PPQ for IPTp in HIV-infected pregnant women receiving CTXp and ARV drugs and using LLITNs will be conducted in Gabon and Mozambique where malaria and HIV infection are moderate to highly prevalent. The possibility of a pharmacokinetic interaction between DHA-PPQ and ARV drugs will be assessed. Women will receive ARV therapy according to national guidelines and their infants will be followed until one year of age to evaluate the impact of DHA-PPQ on MTCT-HIV.

This 5-year project, funded by EDCTP and coordinated by ISGlobal (Barcelona, Spain) in collaboration with the Centre de Recherches Médicales de Lambaréné (CERMEL, Gabon), the Manhiça Health Research Center/ Fundaçao Manhiça (CISM/FM, Mozambique), the Medical University of Vienna (MedUni Wien, Austria), the Bernhard Nocht Institut für Tropenmedizin (BNITM, Germany), and the Eberhard Karls Universitaet Tuebingen (EKUT, Germany) will provide conclusive evidence to reduce the burden of two of the most important poverty-related diseases (PRDs), in HIV-infected pregnant women exposed to malaria.

Total funding: 2,985,000 €

“This project is part of the EDCTP2 programme supported by the European Union”



FAIR - Fighting Antibiotic Resistances


DVT-Study - Deep Vein Thrombosis Study


HHECO - The impact of Helicobacter pylori co-infection on immune regulation and clinical course in HIV patients in Ghana

Recently, the interplay between Human immunodeficiency virus (HIV) and Helicobacter pylori infection has attracted attention. A number of studies reported more favorable immune and clinical parameters in HIV-infected individuals with H. pylori. The inverse relationship between H. pylori infection and immunocompetence of the host is unexpected, since most chronic infections are more common in patients with progressed HIV disease.

We aim to investigate the impact of H. pylori and other relevant co-infections on immune activation and clinical outcomes in a cohort of 1000 HIV-positive patients at the Komfo Anokye Teaching Hospital in Kumasi, Ghana.


KCS - Kumasi Cohort Study on the efficacy of first and second line ART in HIV patients in Ghana

As of 2011, 56 000 adult people living with HIV (PLHIV) were treated with antiretroviral drugs in Ghana. This represents a fourth of all adult PLHIV in Ghana and a 47% coverage among people with advanced HIV infection.

In a cohort of 1500 HIV-infected patients on first-line ART at the Komfo Anokye Teaching Hospital in Kumasi, the proportion of treatment failures and its determinates should be investigated. During this study, we established a cohort of PLHIV switched to second-line ART after virological or immunological treatment failure. Here as well, we aim to investigate the efficacy of this second-line ART, which is of high interest due to the fact that there is no third-line option available in Ghana.

Bernhard Nocht Centre for Clinical Trials (BNCCT)

The Bernhard Nocht Centre for Clinical Trials (BNCCT) is part of the 1st Department of Tropical Medicine of the University Medical Center Hamburg-Eppendorf (UKE). It is located in the historic building of the Bernhard Nocht Institute for Tropical Medicine (BNITM).

Since 2008 the BNCCT performs vaccine trials and offers comprehensive services relating to the conduct of clinical trials in the areas of travel medicine and tropical medicine .

Our services include the management of multicenter clinical trials (e.g. RCTs, IITs), development of regulatory documents, consulting services related to study and protocol design as well as data and safety monitoring.

Further information on the Bernhard Nocht Centre for Clinical Trials (BNCCT) can be found here

Publication Highlights

A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria
Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group.
BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.

Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study
Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, Kakolwa MA, Vala A, Accrombessi M, Briand V, Aponte JJ, Manego Zoleko R, Adegnika AA, Cot M, Kremsner PG, Massougbodji A, Abdulla S, Ramharter M, Macete E, Menéndez C.
PLoS Med. 2016 Feb 23;13(2):e1001964. doi: 10.1371/journal.pmed.1001964. eCollection 2016 Feb.

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA.
N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924. Epub 2015 Apr 1

Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial
Basra A, Mombo-Ngoma G, Melser MC, Diop DA, Würbel H, Mackanga JR, Fürstenau M, Zoleko RM, Adegnika AA, Gonzalez R, Menendez C, Kremsner PG, Ramharter M.
Clin Infect Dis. 2013 Mar;56(6):e68-75. doi: 10.1093/cid/cis976. Epub 2012 Nov 21.

Do paediatric drug formulations of artemisinin combination therapies improve the treatment of children with malaria? A systematic review and meta-analysis
Kurth F, Bélard S, Adegnika AA, Gaye O, Kremsner PG, Ramharter M.
Lancet Infect Dis. 2010 Feb;10(2):125-32. doi: 10.1016/S1473-3099(09)70327-5.

Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon
Ramharter M, Kurth F, Schreier AC, Nemeth J, Glasenapp Iv, Bélard S, Schlie M, Kammer J, Koumba PK, Cisse B, Mordmüller B, Lell B, Issifou S, Oeuvray C, Fleckenstein L, Kremsner PG.
J Infect Dis. 2008 Sep 15;198(6):911-9. doi: 10.1086/591096.

Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial
Ramharter M, Oyakhirome S, Klein Klouwenberg P, Adégnika AA, Agnandji ST, Missinou MA, Matsiégui PB, Mordmüller B, Borrmann S, Kun JF, Lell B, Krishna S, Graninger W, Issifou S, Kremsner PG.
Clin Infect Dis. 2005 Jun 15;40(12):1777-84. Epub 2005 May 3.

Clinical and parasitological characteristics of puerperal malaria
Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG.
J Infect Dis. 2005 Mar 15;191(6):1005-9. Epub 2005 Feb 4.

Shared breastfeeding in central Africa
Ramharter M, Chai SK, Adegnika AA, Klöpfer A, Längin M, Agnandji ST, Oyakhirome S, Schwarz NG, Grobusch MP, Issifou S, Kremsner PG.
AIDS. 2004 Sep 3;18(13):1847-9.

All Publications

2019

Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a Hightransmission Setting
Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Manego Zoleko R, Kim J, Klicpera A, Meyer EL, Blessborn D, Winterberg M, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Fuehrer HP, Ramharter M.
Clin Infect Dis. 2019 Apr 19. pii: ciz131. doi: 10.1093/cid/ciz131. [Epub ahead of print]

Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis
Eberhardt KA, Mischlinger J, Jordan S, Groger M, Günther S, Ramharter M
Int J Infect Dis. 2019 Jul 26;87:15-20. doi: 10.1016/j.ijid.2019.07.015

Measles, vaccines and types of perception bias in public debates.
Mischlinger J, Muranaka R, Bühler S, Ramharter M.
Clin Infect Dis. 2019 Jul 12. pii: ciz586. doi: 10.1093/cid/ciz586. [Epub ahead of print]

A Prospective Study on the Impact and Out-of-Pocket Costs of Dengue Illness in International Travelers.
Tozan Y, Headley TY, Sewe MO, Schwartz E, Shemesh T, Cramer JP, Eberhardt KA, Ramharter M, Harrison N, Leder K, Angheben A, Hatz C, Neumayr A, Chen LH, De Pijper CA, Grobusch MP, Wilder-Smith A.
Am J Trop Med Hyg. 2019 Jun;100(6):1525-1533. doi: 10.4269/ajtmh.18-0780.

Characterization of Plasmodium infections among inhabitants of rural areas in Gabon.
Woldearegai TG, Lalremruata A, Nguyen TT, Gmeiner M, Veletzky L, Tazemda-Kuitsouc GB, Matsiegui PB, Mordmüller B, Held J.
Sci Rep. 2019 Jul 5;9(1):9784. doi: 10.1038/s41598-019-46194-9.

Recombinase polymerase amplification assay for rapid detection of Monkeypox virus.
Davi SD, Kissenkötter J, Faye M, Böhlken-Fascher S, Stahl-Hennig C, Faye O, Faye O, Sall AA, Weidmann M, Ademowo OG, Hufert FT, Czerny CP, Abd El Wahed A.
Diagn Microbiol Infect Dis. 2019 Apr 11. pii: S0732-8893(18)30746-6. doi: 10.1016/j.diagmicrobio.2019.03.015.

Safety and immunogenicity of tetanus/diphtheria vaccination in patients with rheumatic diseases-a prospective multi-centre cohort study.
Bühler S, Jaeger VK, Adler S, Bannert B, Brümmerhoff C, Ciurea A, Distler O, Franz J, Gabay C, Hagenbuch N, Herzog C, Hasler P, Kling K, Kyburz D, Müller R, Nissen MJ, Siegrist CA, Villiger PM, Walker UA, Hatz C.
Rheumatology (Oxford). 2019 Mar 15. pii: kez045. doi: 10.1093/rheumatology/kez045. [Epub ahead of print]

Reiseimpfungen – Hinweise und Empfehlungen. Vaccination for international travel – clinical practice recommendations.
Rothe C, Alberer M, Bühler S, Burchard G, Erkens K, Feldt T, Grobusch MP, Köhler C, Löbermann M, Meischner K, Metzger W, Müller A, Nothdurft H-D, Rieke B, Rosenbusch D, Schlaich C, Schönfeld C, Schulze M, Siedenburg J, Steiner F, Veit O, Boecken G.
Flugmedizin, Tropenmedizin, Reisemedizin. April 2019

Empfehlungen zur Malariaprophylaxe. Recommendations for antimalarial prophylaxis
Rothe C, Boecken G. Rosenbusch D, Alberer M, Bühler S, Burchard G, Erkens K, Feldt T, Grobusch MP, Köhler C, Löbermann M, Meischner K, Metzger W, Müller A, Nothdurft H-D, Rieke B, Schlaich C, Schönfeld C, Schulze M, Siedenburg J, Steiner F, Weitzel T, Veit O.
Flug u Reisemed 2019; 26: 105–132

Flucelvax Tetra: a surface antigen, inactivated, influenza vaccine prepared in cell cultures.
Bühler S, Ramharter M.
ESMO Open. 2019 Jan 21;4(1):e000481. doi: 10.1136/esmoopen-2018-000481. eCollection 2019.

Larva migrans cutanea – eine wichtige Blickdiagnose bei Reiserückkehrern: Larva migrans cutanea – an important visual diagnosis amongst returning travelers.
Omansen TF, Völker K, Ramharter M.
DOI:10.1055/a-0815-9139, Flug u Reisemed 2019; 26: 6–8

2018

Schistosomiasis detected during appendectomy.
Kraef C, Arand J, Veletzky L, Schäfer H, Jordan S, Schmiedel S, Ramharter M.
Lancet. 2018 Jun 23;391(10139):2546. doi: 10.1016/S0140-6736(18)31329-1. No abstract available. PMID: 29976471

Validity and reliability of methods to microscopically detect and quantify malaria parasitaemia.
Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Mombo-Ngoma G, Mordmüller B, Ramharter M.
Trop Med Int Health. 2018 Jun 28. doi: 10.1111/tmi.13124. [Epub ahead of print]

DSM265: a novel drug for single-dose cure of Plasmodium falciparum malaria.
Bélard S, Ramharter M.
Lancet Infect Dis. 2018 Jun 13. pii: S1473-3099(18)30374-8. doi: 10.1016/S1473-3099(18)30374-8. [Epub ahead of print]

Use of Capillary Blood Samples Leads to Higher Parasitemia Estimates and Higher Diagnostic Sensitivity of Microscopic and Molecular Diagnostics of Malaria than Venous Blood Samples.
Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Tannich E, Mombo-Ngoma G, Mordmüller B, Ramharter M.
J Infect Dis. 2018 May 25. doi: 10.1093/infdis/jiy319. [Epub ahead of print]

Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts.
Lötsch F, Mombo-Ngoma G, Mischlinger J, Groger M, Veletzky L, Adegnika AA, Lell B, Agnandji ST, Bouyou-Akotet M, Obermüller M, Wassermann M, Schneider R, Auer H, Ramharter M.
Am J Trop Med Hyg. 2018 Jul;99(1):97-101. doi: 10.4269/ajtmh.17-0955. Epub 2018 May 17.

Dalbavancin as primary and sequential treatment for Gram-positive infective endocarditis: 2-Year Experience at the General Hospital of Vienna.
Tobudic S, Forstner C, Burgmann H, Lagler H, Ramharter M, Steininger C, Vossen MG, Winkler S, Thalhammer F.
Clin Infect Dis. 2018 Apr 5. doi: 10.1093/cid/ciy279. [Epub ahead of print]

Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.
Hede MS, Fjelstrup S, Lötsch F, Zoleko RM, Klicpera A, Groger M, Mischlinger J, Endame L, Veletzky L, Neher R, Simonsen AKW, Petersen E, Mombo-Ngoma G, Stougaard M, Ho YP, Labouriau R, Ramharter M, Knudsen BR.
Sci Rep. 2018 Mar 7;8(1):4122. doi: 10.1038/s41598-018-22378-7.

Behavioural and clinical predictors for Loiasis.
Mischlinger J, Veletzky L, Tazemda-Kuitsouc GB, Pitzinger P, Matsegui PB, Gmeiner M, Lagler H, Gebru T, Held J, Mordmüller B, Ramharter M.
J Glob Health. 2018 Jun;8(1):010413. doi: 10.7189/jogh.08.010413.

Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection.
Veletzky L, Groger M, Lagler H, Walochnik J, Auer H, Fuehrer HP, Ramharter M.
Malar J. 2018 Feb 9;17(1):78. doi: 10.1186/s12936-018-2226-4.

Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon.
Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Zoleko-Manego R, Endamne L, Klicpera A, Kim J, Nguyen T, Flohr L, Remppis J, Matsiegui PB, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Ramharter M.
Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01758-17. doi: 10.1128/AAC.01758-17. Print 2018 Mar.

2017

Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon.
Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Joerg M, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG.
Clin Infect Dis. 2017 Dec 26. doi: 10.1093/cid/cix1122. [Epub ahead of print]

Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial.
Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG.
PLoS Med. 2017 Oct 6;14(10):e1002402. doi: 10.1371/journal.pmed.1002402. eCollection 2017 Oct.

Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing.
Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Bélard S, Mombo-Ngoma G, Ramharter M, Kremsner PG, Mordmüller B, Held J.
Malar J. 2017 Oct 3;16(1):398. doi: 10.1186/s12936-017-2044-0.

FDG-PET/MRI in alveolar echinococcosis.
Lötsch F, Waneck F, Auer H, Kaczirek K, Karanikas G, Ramharter M.
Int J Infect Dis. 2017 Nov;64:67-68. doi: 10.1016/j.ijid.2017.09.006. Epub 2017 Sep 19.

Dalbavancin for outpatient parenteral antimicrobial therapy of skin and soft tissue infections in a returning traveller : Proposal for novel treatment indications.
Mischlinger J, Lagler H, Harrison N, Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):642-645. doi: 10.1007/s00508-017-1243-6. Epub 2017 Aug 3.

Prof. Walther H. Wernsdorfer (1928-2016).
Ramharter M.
Wien Klin Wochenschr. 2017 Sep;129(17-18):650-651. doi: 10.1007/s00508-017-1236-5. Epub 2017 Jul 25.

Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.
Ndam NT, Mbuba E, González R, Cisteró P, Kariuki S, Sevene E, Rupérez M, Fonseca AM, Vala A, Maculuve S, Jiménez A, Quintó L, Ouma P, Ramharter M, Aponte JJ, Nhacolo A, Massougbodji A, Briand V, Kremsner PG, Mombo-Ngoma G, Desai M, Macete E, Cot M, Menéndez C, Mayor A.
BMC Med. 2017 Jul 17;15(1):130. doi: 10.1186/s12916-017-0893-6.

Direct detection of Anaplasma phagocytophilum by polymerase chain reaction followed by electrospray ionization mass spectrometry from human blood.
Lagler H, Harrison N, Kussmann M, Obermüller M, Burgmann H, Makristathis A, Ramharter M.
Int J Infect Dis. 2017 Jul;60:61-63. doi: 10.1016/j.ijid.2017.05.006. Epub 2017 May 16.

Severe malaria in Europe: an 8-year multi-centre observational study.
Kurth F, Develoux M, Mechain M, Malvy D, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Lingscheid T, Kern P, Kapaun A, da Cunha JS, Pongratz P, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T.
Malar J. 2017 Jan 31;16(1):57. doi: 10.1186/s12936-016-1673-z.

Progressive Perforation of the Nasal Septum Due to Leishmania major: A Case of Mucosal Leishmaniasis in a Traveler.
Harrison N, Walochnik J, Ramsebner R, Veletzky L, Lagler H, Ramharter M.
Am J Trop Med Hyg. 2017 Mar;96(3):653-655. doi: 10.4269/ajtmh.16-0809. Epub 2017 Apr 6.

Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon.
Manego RZ, Mombo-Ngoma G, Witte M, Held J, Gmeiner M, Gebru T, Tazemda B, Mischlinger J, Groger M, Lell B, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Ramharter M, Matsiegui PB.
BMC Public Health. 2017 Jan 28;17(1):130. doi: 10.1186/s12889-017-4045-x.

Impact of HIV infection and antiretroviral treatment on N-terminal prohormone of brain natriuretic peptide as surrogate of myocardial function.
Schuster C, Binder C, Strassl R, Aichelburg MC, Blackwell E, Pavo N, Ramharter M, Hülsmann M, Grabmeier-Pfistershammer K, Rieger A, Goliasch G.
AIDS. 2017 Jan 28;31(3):395-400. doi: 10.1097/QAD.0000000000001350.

Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon.
Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, Agobe JC, Lell B, Matsiegui PB, Gonzales R, Agnandji ST, Yazdanbakhsh M, Menendez C, Kremsner PG, Adegnika AA, Ramharter M.
Int J Parasitol. 2017 Jan;47(1):69-74. doi: 10.1016/j.ijpara.2016.11.001. Epub 2016 Dec 18.

Zika virus-induced itching rash in a returning traveller from Brazil.
Veletzky L, Knafl D, Schuster C, Aberle SW, Stiasny K, Ramharter M, Lagler H.
Int J Infect Dis. 2017 Jan;54:13-14. doi: 10.1016/j.ijid.2016.11.004. Epub 2016 Nov 7

2016

Seroprevalence of Toxocara spp. in a rural population in Central African Gabon.
Lötsch F, Obermüller M, Mischlinger J, Mombo-Ngoma G, Groger M, Adegnika AA, Agnandji ST, Schneider R, Auer H, Ramharter M.
Parasitol Int. 2016 Dec;65(6 Pt A):632-634. doi: 10.1016/j.parint.2016.09.001. Epub 2016 Sep 2.

Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania.
Harrison N, Burgmann H, Forstner C, Ramharter M, Széll M, Schötta AM, Stanek G, Markowicz M.
Wien Klin Wochenschr. 2016 Aug;128(15-16):602-5. doi: 10.1007/s00508-016-1047-0. Epub 2016 Aug 3.

Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study.
Mombo-Ngoma G, Mackanga JR, González R, Ouedraogo S, Kakolwa MA, Manego RZ, Basra A, Rupérez M, Cot M, Kabanywany AM, Matsiegui PB, Agnandji ST, Vala A, Massougbodji A, Abdulla S, Adegnika AA, Sevene E, Macete E, Yazdanbakhsh M, Kremsner PG, Aponte JJ, Menéndez C, Ramharter M.
BMJ Open. 2016 Jun 29;6(6):e011783. doi: 10.1136/bmjopen-2016-011783.

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.

Single dose treatment of malaria - current status and perspectives.
Mischlinger J, Agnandji ST, Ramharter M.
Expert Rev Anti Infect Ther. 2016 Jul;14(7):669-78. doi: 10.1080/14787210.2016.1192462. Epub 2016 Jun 7.

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data.
WWARN Gametocyte Study Group.
BMC Med. 2016 May 24;14:79. doi: 10.1186/s12916-016-0621-7.

The first meeting of the European Register of Cystic Echinococcosis (ERCE).
Rossi P, Tamarozzi F, Galati F, Pozio E, Akhan O, Cretu CM, Vutova K, Siles-Lucas M, Brunetti E, Casulli A; HERACLES extended network.
Parasit Vectors. 2016 Apr 28;9:243. doi: 10.1186/s13071-016-1532-3.

Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data.
Lötsch F, Naderer J, Skuhala T, Groger M, Auer H, Kaczirek K, Waneck F, Ramharter M.
Parasitol Res. 2016 Aug;115(8):2995-3001. doi: 10.1007/s00436-016-5054-x. Epub 2016 Apr 16.

Effect of mild medical hypothermia on in vitro growth of Plasmodium falciparum and the activity of anti-malarial drugs.
Rehman K, Sauerzopf U, Veletzky L, Lötsch F, Groger M, Ramharter M.
Malar J. 2016 Mar 15;15:162. doi: 10.1186/s12936-016-1215-8.

Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study.
Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, Kakolwa MA, Vala A, Accrombessi M, Briand V, Aponte JJ, Manego Zoleko R, Adegnika AA, Cot M, Kremsner PG, Massougbodji A, Abdulla S, Ramharter M, Macete E, Menéndez C.
PLoS Med. 2016 Feb 23;13(2):e1001964. doi: 10.1371/journal.pmed.1001964. eCollection 2016 Feb.

Anaplasmataceae-Specific PCR for Diagnosis and Therapeutic Guidance for Symptomatic Neoehrlichiosis in Immunocompetent Host.
Schwameis M, Auer J, Mitteregger D, Simonitsch-Klupp I, Ramharter M, Burgmann H, Lagler H.
Emerg Infect Dis. 2016 Feb;22(2):281-4. doi: 10.3201/eid2202.141762.

Alterations of blood coagulation in controlled human malaria infection.
Riedl J, Mordmüller B, Koder S, Pabinger I, Kremsner PG, Hoffman SL, Ramharter M, Ay C.
Malar J. 2016 Jan 7;15:15. doi: 10.1186/s12936-015-1079-3.

2015

Imported malaria in pregnant women: A retrospective pooled analysis.
Käser AK, Arguin PM, Chiodini PL, Smith V, Delmont J, Jiménez BC, Färnert A, Kimura M, Ramharter M, Grobusch MP, Schlagenhauf P.
Travel Med Infect Dis. 2015 Jul-Aug;13(4):300-10. doi: 10.1016/j.tmaid.2015.06.011. Epub 2015 Jul 9.

Activity of antimicrobial drugs against bacterial pathogens under mild hypothermic conditions.
Wallmüller C, Herold B, Sterz F, Makristathis A, Ramharter M.
Am J Emerg Med. 2015 Oct;33(10):1445-8. doi: 10.1016/j.ajem.2015.07.005. Epub 2015 Jul 4.

Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns--A cross-sectional delivery survey in Central Gabon.
Capan-Melser M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Manego-Zoleko R, Würbel H, Lötsch F, Groger M, Skoll M, Schwing J, Schipulle U, Matsiegui PB, González R, Menendez C, Kremsner PG, Adegnika AA, Agnandji ST, Ramharter M.
Int J Infect Dis. 2015 Oct;39:16-9. doi: 10.1016/j.ijid.2015.08.004. Epub 2015 Aug 10.

Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study.
Kurth F, Develoux M, Mechain M, Clerinx J, Antinori S, Gjørup IE, Gascon J, Mørch K, Nicastri E, Ramharter M, Bartoloni A, Visser L, Rolling T, Zanger P, Calleri G, Salas-Coronas J, Nielsen H, Just-Nübling G, Neumayr A, Hachfeld A, Schmid ML, Antonini P, Pongratz P, Kern P, Saraiva da Cunha J, Soriano-Arandes A, Schunk M, Suttorp N, Hatz C, Zoller T; TropNet Severe Malaria Investigator Group.
Clin Infect Dis. 2015 Nov 1;61(9):1441-4. doi: 10.1093/cid/civ575. Epub 2015 Jul 17.

Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy.
Sicuri E, Fernandes S, Macete E, González R, Mombo-Ngoma G, Massougbodgi A, Abdulla S, Kuwawenaruwa A, Katana A, Desai M, Cot M, Ramharter M, Kremsner P, Slustker L, Aponte J, Hanson K, Menéndez C.
PLoS One. 2015 Apr 27;10(4):e0125072. doi: 10.1371/journal.pone.0125072. eCollection 2015.

Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine.
Capan-Melser M, Mombo Ngoma G, Akerey-Diop D, Basra A, Würbel H, Groger M, Mackanga JR, Zoleko-Manego R, Schipulle U, Schwing J, Lötsch F, Rehman K, Matsiegui PB, Agnandji ST, Adegnika AA, Bélard S, González R, Kremsner PG, Menendez C, Ramharter M.
J Antimicrob Chemother. 2015;70(6):1898-902. doi: 10.1093/jac/dkv041. Epub 2015 Feb 25.

Loa loa Infection in Pregnant Women, Gabon.
Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, Lötsch F, Yazdanbakhsh M, González R, Menendez C, Mabika B, Matsiegui PB, Kremsner PG, Ramharter M.
Emerg Infect Dis. 2015 May;21(5):899a-901. doi: 10.3201/eid2105.141471.

Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria.
Lötsch F, Auer-Hackenberg L, Groger M, Rehman K, Morrison V, Holmes E, Parveen S, Plumpton C, Clyne W, de Geest S, Dobbels F, Vrijens B, Kardas P, Hughes D, Ramharter M.
Wien Klin Wochenschr. 2015 May;127(9-10):379-84. doi: 10.1007/s00508-015-0782-y. Epub 2015 Apr 24.

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.
WWARN Parasite Clearance Study Group, Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D'Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA.
Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.

Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.
Agnandji ST, Fernandes JF, Bache EB, Ramharter M.
Future Microbiol. 2015;10(10):1553-78. doi: 10.2217/fmb.15.90. Epub 2015 Oct 6.

Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.
Belard S, Toepfner N, Capan-Melser M, Mombo-Ngoma G, Zoleko-Manego R, Groger M, Matsiegui PB, Agnandji ST, Adegnika AA, González R, Kremsner PG, Menendez C, Ramharter M, Berner R.
Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.

Hepatosplenic Abscesses and Osteomyelitis of the Spine in an Immunocompetent Adult with Cat Scratch Disease.
Knafl D, Lötsch F, Burgmann H, Goliasch G, Poeppl W, Ramharter M, Thalhammer F, Schuster C
Case Rep Infect Dis. 2015;2015:317260. doi: 10.1155/2015/317260. Epub 2015 Oct 21.

Case report: spontaneous rupture of spleen in patient with Plasmodium ovale malaria.
Lemmerer R, Unger M, Voßen M, Forstner C, Jalili A, Starzengruber P, Werzowa J, Ramharter M, Winkler S, Thalhammer F.
Wien Klin Wochenschr. 2016 Jan;128(1-2):74-7. doi: 10.1007/s00508-015-0888-2. Epub 2015 Nov 5.

Neither Single nor a Combination of Routine Laboratory Parameters can Discriminate between Gram-positive and Gram-negative Bacteremia.
Ratzinger F, Dedeyan M, Rammerstorfer M, Perkmann T, Burgmann H, Makristathis A, Dorffner G, Loetsch F, Blacky A, Ramharter M.
Sci Rep. 2015 Nov 2;5:16008. doi: 10.1038/srep16008.

Population Pharmacokinetics of Pyronaridine in Pediatric Malaria Patients.
Ayyoub A, Methaneethorn J, Ramharter M, Djimde AA, Tekete M, Duparc S, Borghini-Fuhrer I, Shin JS, Fleckenstein L.
Antimicrob Agents Chemother. 2015 Dec 14;60(3):1450-8. doi: 10.1128/AAC.02004-15.

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana.
Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Oteng-Seifah EE, Bedu-Addo G, Phillips RO, Norman B, Burchard G, Feldt T.
PLoS One. 2015 Nov 24;10(11):e0143388. doi: 10.1371/journal.pone.0143388. eCollection 2015.

Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Eberhardt KA, Sarfo FS, Dompreh A, Kuffour EO, Geldmacher C, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Bedu-Addo G, Phillips RO, Norman B, Burchard GD, Feldt T.
Clin Infect Dis. 2015 Nov 15;61(10):1615-23. doi: 10.1093/cid/civ577. Epub 2015 Jul 20.

Group B Streptococci serotype distribution in pregnant women in Ghana: assessment of potential coverage through future vaccines.
Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y, Rolling T, Dekker D, Adu-Sarkodie Y, Eberhardt KA, May J, Cramer JP.
Trop Med Int Health. 2015 Nov;20(11):1516-1524. doi: 10.1111/tmi.12589.

CCN1 mutation is associated with atrial septal defect.
Perrot A, Schmitt KR, Roth EM, Stiller B, Posch MG, Browne EN, Timmann C, Horstmann RD, Berger F, Özcelik C.
Pediatr Cardiol. 2015 Feb;36(2):295-9. doi: 10.1007/s00246-014-1001-8. Epub 2014 Aug 19.